3cc4: Difference between revisions

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-[[Image:3cc4.png|left|200px]]
-<!--
+==Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit==
-The line below this paragraph, containing "STRUCTURE_3cc4", creates the "Structure Box" on the page.
+<StructureSection load='3cc4' size='340' side='right'caption='[[3cc4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3cc4]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CC4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1MA:6-HYDRO-1-METHYLADENOSINE-5-MONOPHOSPHATE'>1MA</scene>, <scene name='pdbligand=ANM:ANISOMYCIN'>ANM</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OMG:O2-METHYLGUANOSINE-5-MONOPHOSPHATE'>OMG</scene>, <scene name='pdbligand=OMU:O2-METHYLURIDINE+5-MONOPHOSPHATE'>OMU</scene>, <scene name='pdbligand=PSU:PSEUDOURIDINE-5-MONOPHOSPHATE'>PSU</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=UR3:3-METHYLURIDINE-5-MONOPHOSHATE'>UR3</scene></td></tr>
-{{STRUCTURE_3cc4|  PDB=3cc4  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cc4 OCA], [https://pdbe.org/3cc4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cc4 RCSB], [https://www.ebi.ac.uk/pdbsum/3cc4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cc4 ProSAT]</span></td></tr>
+</table>
-===Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit===
+== Function ==
+[https://www.uniprot.org/uniprot/RL2_HALMA RL2_HALMA] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_A]
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_18455733}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 18455733 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/3cc4_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_18455733}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[3cc4]] is a 30 chain structure of [[Ribosomal protein L10]], [[Ribosomal protein L2]], [[Ribosomal protein L3]], [[Ribosomal protein L4]], [[Ribosomal protein L5]], [[Ribosomal protein L6]], [[Ribosomal protein L7]] and [[Ribosome]] with sequence from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CC4 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cc4 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Ribosomal protein L10]]
+*[[Ribosome 3D structures|Ribosome 3D structures]]
-*[[Ribosomal protein L2]]
+__TOC__
-*[[Ribosomal protein L3]]
+</StructureSection>
-*[[Ribosomal protein L4]]
-*[[Ribosomal protein L5]]
-*[[Ribosomal protein L6]]
-*[[Ribosomal protein L7]]
-*[[Ribosome]]
-==Reference==
-<ref group="xtra">PMID:18455733</ref><ref group="xtra">PMID:12860128</ref><references group="xtra"/>
-[[Category: Haloarcula marismortui]]
-[[Category: Blaha, G.]]
-[[Category: Gurel, G.]]
-[[Category: Anisomycin]]
-[[Category: Co-crystal]]
 [[Category: Haloarcula marismortui]]
-[[Category: Large ribosomal subunit]]
+[[Category: Large Structures]]
-[[Category: Ribosome]]
+[[Category: Blaha G]]
-[[Category: Wild type]]
+[[Category: Gurel G]]