Tubulin: Difference between revisions

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Alexander Berchansky, Michal Harel, Joel L. Sussman

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-[[Image:1z5w.png|left|200px|thumb|Crystal Structure of Tubulin [[1z5w]]]]
+<StructureSection load='' size='350' side='right' caption='γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]]' scene='43/430888/Cv/2' pspeed='8'>
-{{STRUCTURE_1z5w|  PDB=1z5w  | SIZE=300| SCENE= |right|CAPTION=Tubulin [[1z5w]] }}
+== Function ==
-[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes.  Microtubules are assembled from dimers of alpha-tubulin (TUBA) and beta-tubulin (TUBB) bound to GTP.  Gamma-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes.  FtsZ  (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. The images at the left and at the right correspond to one representative Tubulin, ''i.e.'' the crystal structure of Tubulin ([[1z5w]]).
+[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes.  Microtubules are assembled from dimers of '''α-tubulin''' (TUBA) and '''β-tubulin''' (TUBB) bound to GTP. '''γ-tubulin''' (TUBG) is part of the nucleation of microtubules<ref>PMID:11297925</ref>. Human TUB contains several numbered subtypes.  Tubulin filaments are stabilized by taxol and zampanolide.  '''FtsZ'''  (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB<ref>PMID:26463348</ref>. See [[Cell division protein]] and [[Beta tubulin]].
-{{TOC limit|limit=2}}
+== Relevance ==
-== 3D Structures of Tubulin ==
+The chemotherapeutic drug Taxol interacts with TUBB.  See [[Molecular Playground/Taxol]].  TUBA and TUBB expression in polyps of invasive colon cancer is different from normal<ref>PMID:16101133</ref>.
+See [[Paclitaxel]].
-=== Tubulin ===
+== Disease ==
+Mutations in TUBB underlie a large spectrum of neuronal migration disorders<ref>PMID:19465910</ref>.
-[[3hkb]], [[3hkc]], [[3hkd]], [[3hke]] – TUBA+TUBB+stathmin-like protein B3 – sheep<br />
-[[2wbe]] – cTUBA1D+cTUBB2B+kinesin+AMPPNP – cow<br />
-[[3dco]] - cTUBA+cTUBB+kinesin-like NOD<br />
-[[1tvk]] - cTUBA+cTUBB+GDP+GTP+Epothilone A – electron crystallography<br />
-[[3edl]] - cTUBA1D+cTUBB2B+kinesin motor domain<br />
-[[3du7]], [[3e22]], [[1z2b]], [[1sa0]], [[1sa1]] – cTUBA1C+cTUBB2B+stathmin-like protein B3<br />
-[[1ffx]] - cTUBA+cTUBB+stathmin-like protein B3<br />
-[[1jff]] - cTUBA+cTUBB<br />
-[[2p4n]] - hTUBA+hTUBB+kinesin heavy chain<br />
-[[3cb2]] – hTUBG1+GDP<br />
-[[1z5v]] - hTUBG1+GTPgS<br />
-[[1z5w]] - hTUBG1+GTP<br />
-[[2hxf]] - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP – pig<br />
-[[2hxh]] - pTUBA+pTUBB+kinesin-like KIF1A+ADP<br />
-[[1ia0]] - pTUBA+pTUBB+kinesin-like KIF1A+ATP<br />
-[[1tub]] - pTUBA+pTUBB – electron diffraction<br />
-[[2bto]] – PdTUBA+thioredoxin 1 – ''Prosthecobacter dejongeii''<br />
-[[2btq]] – PdTUBA+PdTUBB
+== Structural highlights ==
+*<scene name='43/430888/Cv/6'>γ-tubulin interactions with GTP and Mg+2 ion</scene> ([[1z5w]]).
+== 3D Structures of Tubulin ==
+[[Tubulin 3D Structures]]
-=== FtsZ ===
+</StructureSection>
-rhh, 2rhj – BsFtsZ+SO4 – Bacillus subtilis
+== References ==
-rhl - BsFtsZ+GDP
+<references/>
-rho - BsFtsZ+GDP+GTP-gamma-S
+[[Category:Topic Page]]
-vxy, 2vam – BsFtsZ
-ve8 – PaFtsZ gamma domain – Pseudomonas aeruginosa
-ve9 - PaFtsZ gamma domain+DNA
-vaw – PaFtsZ+GDP
-ofu - PaFtsZ+SULA
-r75 - AaFtsZ+8-morpholino-GTP – Aquifex aeolicus
-r6r - AaFtsZ
-q1x, 1rq2 - MtFtsZ+citrate – Mycobacterium tuberculosis
-q1y, 1rlu - MtFtsZ+GTP-gamma-S
-rq7 - MtFtsZ+GDP
-vap – MjFtsZ+GDP – Methancaldococcus jannaschii
-w58 - MjFtsZ+GMPCPP
-w59, 1fsz – MjFtsZ
-w5a - MjFtsZ+MgGTP
-w5b - MjFtsZ+GTP
-w5e, 1w5f – MjFtsZ (mutant)

Tubulin: Difference between revisions

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