Thioredoxin: Difference between revisions

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-[[Image:1ert.png|left|200px|thumb|Crystal Structure of Thioredoxin [[1ert]]]]
+<StructureSection load='' size='350' side='right' caption='Human thioredoxin (PDB entry [[1ert]])' scene='43/430885/Cv/2'>
-{{STRUCTURE_1ert|  PDB=1ert  | SIZE=300| SCENE=Thioredoxin/Cv/1 |right|CAPTION=Thioredoxin [[1ert]] }}
+== Function ==
+[[Thioredoxin]] (Trx) is an enzyme which facilitates, in its reduced form,  the reduction of proteins by cysteine thiol-disulfide exchange<ref>PMID:3152490</ref>.  They contain a CXXC motif.<br />
+* '''Trx-1''' is a mammalian cellular protein.<br />
+*  '''Trx-2''' is mitochondria-specific.<br />
+*  '''Trx C,M,X,Y''' are found in prokaryotes.<br />
+*  '''Trx F,H,O''' are found in eukaryotes.<br />
+== Relevance ==
+Serum Trx level is a predictor of steatohepatitis<ref>PMID:12480557</ref>.
+== Disease ==
+Trx is involved in a wide range of human diseases and conditions including cancer, viral diseases, aging, cardiac conditions and more<ref>PMID:15990177</ref>.
+== Structural highlights ==
+The <scene name='43/430885/Cv/4'>active site motif Cys-Gly-Pro-Cys</scene> is involved in the reduction of disulfide bonds in proteins<ref>PMID:8805557</ref>
+== 3D Structures of Thioredoxin ==
+[[Thioredoxin 3D structures]]
+</StructureSection>
+== References ==
+<references/>
+[[Category:Topic Page]]