Fibronectin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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-[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]]
+<StructureSection load='3m7p' size='350' side='right' scene='43/430871/Cv/2' caption='Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code [[3m7p]]) '>
-{{STRUCTURE_1fbr|  PDB=1fbr  | SIZE=300| SCENE= |right|CAPTION=Fibronectin 4-5FnI fragment [[1fbr]] }}
-[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others.  It is a component of cell adhesion.  It is a dimer of homologous monomers linked by S-S bond.  Each monomer contains 3 types of modules: FnI, FnII and FnIII.  Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment  ([[1fbr]]).
+== Function ==
-{{TOC limit|limit=2}}
+[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others.  It is a component of cell adhesion<ref>PMID:12244123</ref>.
-== 3D Structures of Fibronectin ==
+== Relevance ==
+Fn is associated with wound healing. Fn is a potential marker for radiation resistance.
-=== Fn module FnI ===
+== Disease ==
-[[3m7p]] – hFn GBD – human
+Overexpression of Fn1 is associated with lung cancer<ref>PMID:16397245</ref>.
-e8b, 1e88, 1qo6 - hFn GBD – NMR
-gxe, 3ejh – hFn 8-9FnI+collagen alpha-1
-fbr - hFn 4-5FnI
-rky, 2rl0 – hFn 4-5FnI+Fn binding peptide
-rkz, 3cal - hFn 2-3FnI+Fn binding peptide
-cg6, 2cg7 - hFn 2-3FnI
-cku - hFn 2-3FnI – NMR
-o9a - hFn 1-2FnI+B3 from FNBB – NMR
-ec3 – hFn 11FnI – NMR
-qgb – hFn FnI N-terminal - NMR
-ck2 – hFn (mutant) core swapped
-j8k – hFn extra domain 2 – NMR
-fnh – hFn heparin and integrin binding domains
+== Structural insights ==
-=== Fn module FnII ===
+<scene name='43/430871/Cv/3'>Fn is a dimer of homologous monomers</scene> linked by S-S bond.  Each monomer contains 3 types of modules: FnI, FnII and FnIII.  Each module contains several numbered protein binding domains, i.e., FnI<sub>6</sub>-FnII<sub>1-2</sub>-FnI<sub>7-9</sub> is the gelatin binding domain (GBD).
-fn2 – hFn 2FnII – NMR
+== 3D Structures of Fibronectin ==
+[[Fibronectin 3D structures]]
+</StructureSection>
-=== Fn module FnIII ===
+== References ==
+<references/>
-h41, 2h45 – hFn 2FnIII – NMR
+[[Category:Topic Page]]
-oww - hFn 1FnIII – NMR
-ha1 - hFn 1-2FnIII – NMR
-crm - hFn 4FnIII – NMR
-crz - hFn 5FnIII – NMR
-fna, 1ttf, 1ttg – hFn 10FnIII
-fnf – hFn 7-10FnIII
-fnb – hFn FnIII ed-b domain – NMR
-mfn, 2mfn – Fn 9-10FnIII – mouse - NMR