2rhg: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2rhg.jpg|left|200px]]<br /><applet load="2rhg" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2rhg, resolution 2.00&Aring;" />
-'''Tryptophan synthase complexed with IGP, pH 7.0, internal aldimine'''<br />
-==About this Structure==
+==Tryptophan synthase complexed with IGP, pH 7.0, internal aldimine==
-RHG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium] with <scene name='pdbligand=NA:'>NA</scene>, <scene name='pdbligand=IGP:'>IGP</scene> and <scene name='pdbligand=PLP:'>PLP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RHG OCA].
+<StructureSection load='2rhg' size='340' side='right'caption='[[2rhg]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-[[Category: Protein complex]]
+== Structural highlights ==
-[[Category: Salmonella typhimurium]]
+<table><tr><td colspan='2'>[[2rhg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RHG FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IGP:INDOLE-3-GLYCEROL+PHOSPHATE'>IGP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.20 4.2.1.20] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rhg OCA], [https://pdbe.org/2rhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rhg RCSB], [https://www.ebi.ac.uk/pdbsum/2rhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rhg ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[https://www.uniprot.org/uniprot/TRPA_SALTY TRPA_SALTY]] The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. [[https://www.uniprot.org/uniprot/TRPB_SALTY TRPB_SALTY]] The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/2rhg_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rhg ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Tryptophan synthase 3D structures|Tryptophan synthase 3D structures]]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Tryptophan synthase]]
-[[Category: Barends, T.]]
+[[Category: Barends, T]]
-[[Category: Kulik, V.]]
+[[Category: Kulik, V]]
-[[Category: Schlichting, I.]]
+[[Category: Schlichting, I]]
-[[Category: IGP]]
+[[Category: Allosteric enzyme]]
-[[Category: NA]]
+[[Category: Amino-acid biosynthesis]]
-[[Category: PLP]]
+[[Category: Aminoacid biosynthesis]]
-[[Category: allosteric enzyme]]
+[[Category: Aromatic amino acid biosynthesis]]
-[[Category: amino-acid biosynthesis]]
+[[Category: Carbon-oxygen lyase]]
-[[Category: aminoacid biosynthesis]]
+[[Category: Lyase]]
-[[Category: aromatic amino acid biosynthesis]]
+[[Category: Pyridoxal phosphate]]
-[[Category: carbon-oxygen lyase]]
+[[Category: Tryptophan biosynthesis]]
-[[Category: lyase]]
-[[Category: pyridoxal phosphate]]
-[[Category: tryptophan biosynthesis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:10:45 2008''