3pls: Difference between revisions

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==RON in complex with ligand AMP-PNP==
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<StructureSection load='3pls' size='340' side='right'caption='[[3pls]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3pls]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PLS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3pls|  PDB=3pls  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pls FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pls OCA], [https://pdbe.org/3pls PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pls RCSB], [https://www.ebi.ac.uk/pdbsum/3pls PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pls ProSAT]</span></td></tr>
 
</table>
===RON in complex with ligand AMP-PNP===
== Function ==
 
[https://www.uniprot.org/uniprot/RON_HUMAN RON_HUMAN] Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.<ref>PMID:7939629</ref> <ref>PMID:9764835</ref> <ref>PMID:18836480</ref>
 
== References ==
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{{ABSTRACT_PUBMED_20726546}}
 
==About this Structure==
3PLS is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PLS OCA].  
 
==Reference==
<ref group="xtra">PMID:20726546</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Large Structures]]
[[Category: Augustin, M.]]
[[Category: Augustin M]]
[[Category: Crew, A P.]]
[[Category: Crew AP]]
[[Category: Epstein, D.]]
[[Category: Epstein D]]
[[Category: Mulvihill, M J.]]
[[Category: Mulvihill MJ]]
[[Category: Schreiner, P.]]
[[Category: Schreiner P]]
[[Category: Steinbacher, S.]]
[[Category: Steinbacher S]]
[[Category: Wang, J.]]
[[Category: Wang J]]
[[Category: Amp-pnp]]
[[Category: Cis autophosphorylation conformation]]
[[Category: Protein kinase]]
[[Category: Receptor tyrosine kinase]]
[[Category: Single-span transmembrane receptor]]
[[Category: Transferase]]
[[Category: Unphosphorylated]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 24 14:21:12 2010''

Latest revision as of 13:41, 21 February 2024

RON in complex with ligand AMP-PNPRON in complex with ligand AMP-PNP

Structural highlights

3pls is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.24Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RON_HUMAN Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.[1] [2] [3]

References

  1. ↑ Wang MH, Ronsin C, Gesnel MC, Coupey L, Skeel A, Leonard EJ, Breathnach R. Identification of the ron gene product as the receptor for the human macrophage stimulating protein. Science. 1994 Oct 7;266(5182):117-9. PMID:7939629
  2. ↑ Nanney LB, Skeel A, Luan J, Polis S, Richmond A, Wang MH, Leonard EJ. Proteolytic cleavage and activation of pro-macrophage-stimulating protein and upregulation of its receptor in tissue injury. J Invest Dermatol. 1998 Oct;111(4):573-81. PMID:9764835 doi:http://dx.doi.org/10.1046/j.1523-1747.1998.00332.x
  3. ↑ Feres KJ, Ischenko I, Hayman MJ. The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells. Oncogene. 2009 Jan 15;28(2):279-88. doi: 10.1038/onc.2008.383. Epub 2008 Oct 6. PMID:18836480 doi:http://dx.doi.org/10.1038/onc.2008.383

3pls, resolution 2.24Å

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