3nbq: Difference between revisions

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[[Image:3nbq.png|left|200px]]


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==Human uridine phosphorylase 1 (hUPP1) with 5-fluorouracil==
The line below this paragraph, containing "STRUCTURE_3nbq", creates the "Structure Box" on the page.
<StructureSection load='3nbq' size='340' side='right'caption='[[3nbq]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3nbq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NBQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=URF:5-FLUOROURACIL'>URF</scene></td></tr>
{{STRUCTURE_3nbq| PDB=3nbq |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nbq OCA], [https://pdbe.org/3nbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nbq RCSB], [https://www.ebi.ac.uk/pdbsum/3nbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nbq ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UPP1_HUMAN UPP1_HUMAN] Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/3nbq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nbq ConSurf].
<div style="clear:both"></div>


===Human uridine phosphorylase 1 (hUPP1) with 5-fluorouracil===
==See Also==
 
*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
 
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{{ABSTRACT_PUBMED_20856879}}
 
==About this Structure==
3NBQ is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NBQ OCA].
 
==Reference==
<ref group="xtra">PMID:20856879</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Uridine phosphorylase]]
[[Category: Large Structures]]
[[Category: Roosild, T P.]]
[[Category: Roosild TP]]
[[Category: 5-fluorouracil]]
[[Category: Chemotherapy]]
[[Category: Nucleoside phosphorylase]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:10:19 2010''

Latest revision as of 13:29, 21 February 2024

Human uridine phosphorylase 1 (hUPP1) with 5-fluorouracilHuman uridine phosphorylase 1 (hUPP1) with 5-fluorouracil

Structural highlights

3nbq is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.3Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

UPP1_HUMAN Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3nbq, resolution 2.30Å

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