B-RAF with PLX4032: Difference between revisions

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==This is a placeholder==
==B-RAF with PLX4032==
This is a placeholder text to help you get started in
PLX4032 is a newly synthesized drug that is being used to treat malignant melanoma with a specific mutation. The mutation is B-RAF^(V600E). This drug is highly selective for this mutation and will not bind to wild type B-RAF.  
placing a Jmol applet on your page. At any time, click
"Show Preview" at the bottom of this page to see how it goes.


Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
and display another structure.


<scene name='B-RAF_with_PLX4032/Plx_4032_only/1'>PLX 4032</scene><br>
 
<scene name='B-RAF_with_PLX4032/V600e_mutation/1'>V600E mutation</scene>
<applet load='3og7' size='400' color='white' frame='true' align='right' caption='BRAF kinase domain complex with PLX4032 (PDB code [[3og7]])' />
<applet load='3og7' size='700' color='white' frame='true' align='center' caption='testcaption' />
<scene name='B-RAF_with_PLX4032/Plx_4032_only/2'>PLX 4032</scene><br>
<scene name='B-RAF_with_PLX4032/Atp/2'>ATP</scene><br>
<scene name='B-RAF_with_PLX4032/Wild-type_b-raf/2'>Wild-Type B-RAF</scene> <br>
<scene name='B-RAF_with_PLX4032/Mutated_v600e/2'>V600E Mutation</scene> <br>
<scene name='B-RAF_with_PLX4032/H-bond/4'>H-Bond Interaction Asp594 and PLX4032</scene><br>
<scene name='B-RAF_with_PLX4032/Superposition3og71uwh/4'>Superposition overview</scene> <br>
<scene name='B-RAF_with_PLX4032/Superposition3og71uwh/5'>Superposition close up</scene> <br>
<scene name='B-RAF_with_PLX4032/Superposition3og71uwh/2'>Superposition active site</scene> <br>

Latest revision as of 12:49, 3 January 2019

B-RAF with PLX4032B-RAF with PLX4032

PLX4032 is a newly synthesized drug that is being used to treat malignant melanoma with a specific mutation. The mutation is B-RAF^(V600E). This drug is highly selective for this mutation and will not bind to wild type B-RAF.


BRAF kinase domain complex with PLX4032 (PDB code 3og7)

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Jens Hemmingsen, J.D. Woodruff, Michal Harel
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