2kpf: Difference between revisions

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-{{Seed}}
-[[Image:2kpf.jpg|left|200px]]
-<!--
+==Spatial structure of the dimeric transmembrane domain of glycophorin A in bicelles soluton==
-The line below this paragraph, containing "STRUCTURE_2kpf", creates the "Structure Box" on the page.
+<StructureSection load='2kpf' size='340' side='right'caption='[[2kpf]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2kpf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KPF FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpf OCA], [https://pdbe.org/2kpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpf RCSB], [https://www.ebi.ac.uk/pdbsum/2kpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpf ProSAT]</span></td></tr>
-{{STRUCTURE_2kpf|  PDB=2kpf  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GLPA_HUMAN GLPA_HUMAN] Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).<ref>PMID:8009226</ref> <ref>PMID:10926825</ref> <ref>PMID:12813056</ref> <ref>PMID:14604989</ref> <ref>PMID:15331714</ref> <ref>PMID:19438409</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kp/2kpf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kpf ConSurf].
+<div style="clear:both"></div>
-===Spatial structure of the dimeric transmembrane domain of glycophorin A in bicelles soluton===
+==See Also==
+*[[Endonuclease 3D structures|Endonuclease 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-KPF is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPF OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arseniev, A S.]]
+[[Category: Large Structures]]
-[[Category: Bocharov, E V.]]
+[[Category: Arseniev AS]]
-[[Category: Efremov, R G.]]
+[[Category: Bocharov EV]]
-[[Category: Goncharuk, M V.]]
+[[Category: Efremov RG]]
-[[Category: Mineev, K S.]]
+[[Category: Goncharuk MV]]
-[[Category: Volynsky, P E.]]
+[[Category: Mineev KS]]
-[[Category: Bicelle]]
+[[Category: Volynsky PE]]
-[[Category: Blood group antigen]]
-[[Category: Cell membrane]]
-[[Category: Glycophorin some]]
-[[Category: Glycoprotein]]
-[[Category: Host-virus interaction]]
-[[Category: Membrane]]
-[[Category: Membrane protein]]
-[[Category: Micelle]]
-[[Category: Sialic acid]]
-[[Category: Transmembrane]]
-[[Category: Transmembrane dimer]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:41:18 2010''