3kr7: Difference between revisions

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-{{Seed}}
-[[Image:3kr7.png|left|200px]]
-<!--
+==Human tankyrase 2 - catalytic PARP domain==
-The line below this paragraph, containing "STRUCTURE_3kr7", creates the "Structure Box" on the page.
+<StructureSection load='3kr7' size='340' side='right'caption='[[3kr7]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3kr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KR7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3kr7|  PDB=3kr7  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kr7 OCA], [https://pdbe.org/3kr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kr7 RCSB], [https://www.ebi.ac.uk/pdbsum/3kr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kr7 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kr/3kr7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kr7 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We report two crystal structures of the PARP domain of human tankyrase-2 (TNKS2). Tankyrases are involved in fundamental cellular processes such as telomere homeostasis and Wnt signaling. The complex of TNKS2 with the potent inhibitor XAV939 provides insights into the molecular basis of the strong interaction and suggests routes for further development of tankyrase inhibitors.
-===Human tankyrase 2 - catalytic PARP domain===
+Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.,Karlberg T, Markova N, Johansson I, Hammarstrom M, Schutz P, Weigelt J, Schuler H J Med Chem. 2010 Jul 22;53(14):5352-5. PMID:20565110<ref>PMID:20565110</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3kr7" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20565110}}, adds the Publication Abstract to the page
+*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20565110 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20565110}}
+__TOC__
+</StructureSection>
-==About this Structure==
-KR7 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KR7 OCA].
-==Reference==
-<ref group="xtra">PMID:20565110</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Berg, S Van Den.]]
+[[Category: Arrowsmith CH]]
-[[Category: Berglund, H.]]
+[[Category: Berglund H]]
-[[Category: Bountra, C.]]
+[[Category: Bountra C]]
-[[Category: Collins, R.]]
+[[Category: Collins R]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Flodin, S.]]
+[[Category: Flodin S]]
-[[Category: Flores, A.]]
+[[Category: Flores A]]
-[[Category: Graslund, S.]]
+[[Category: Graslund S]]
-[[Category: Hammarstrom, M.]]
+[[Category: Hammarstrom M]]
-[[Category: Johansson, A.]]
+[[Category: Johansson A]]
-[[Category: Johansson, I.]]
+[[Category: Johansson I]]
-[[Category: Kallas, A.]]
+[[Category: Kallas A]]
-[[Category: Karlberg, T.]]
+[[Category: Karlberg T]]
-[[Category: Kotenyova, T.]]
+[[Category: Kotenyova T]]
-[[Category: Kotzsch, A.]]
+[[Category: Kotzsch A]]
-[[Category: Kraulis, P.]]
+[[Category: Kraulis P]]
-[[Category: Moche, M.]]
+[[Category: Moche M]]
-[[Category: Nielsen, T K.]]
+[[Category: Nielsen TK]]
-[[Category: Nordlund, P.]]
+[[Category: Nordlund P]]
-[[Category: Nyman, T.]]
+[[Category: Nyman T]]
-[[Category: Persson, C.]]
+[[Category: Persson C]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Schuler H]]
-[[Category: Schuler, H.]]
+[[Category: Schutz P]]
-[[Category: Schutz, P.]]
+[[Category: Siponen MI]]
-[[Category: Siponen, M I.]]
+[[Category: Thorsell AG]]
-[[Category: Thorsell, A G.]]
+[[Category: Tresaugues L]]
-[[Category: Tresaugues, L.]]
+[[Category: Van Den Berg S]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt J]]
-[[Category: Welin, M.]]
+[[Category: Welin M]]
-[[Category: Wisniewska, M.]]
+[[Category: Wisniewska M]]
-[[Category: Adp-ribosylation]]
-[[Category: Ank repeat]]
-[[Category: Catalytic fragment]]
-[[Category: Chromosomal protein]]
-[[Category: Glycosyltransferase]]
-[[Category: Golgi apparatus]]
-[[Category: Membrane]]
-[[Category: Mrna transport]]
-[[Category: Nad]]
-[[Category: Nuclear pore complex]]
-[[Category: Nucleus]]
-[[Category: Parp]]
-[[Category: Phosphorylation]]
-[[Category: Protein transport]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Telomere]]
-[[Category: Transferase]]
-[[Category: Translocation]]
-[[Category: Transport]]
-[[Category: Wnt-signalling]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Sep 10 13:35:57 2010''