3oa1: Difference between revisions

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-{{Seed}}
-[[Image:3oa1.jpg|left|200px]]
-<!--
+==Crystal structure of phosphoprotein/Protein P/Protein M1 residues 69-297 from Rabies virus reveals degradation to C-terminal domain only==
-The line below this paragraph, containing "STRUCTURE_3oa1", creates the "Structure Box" on the page.
+<StructureSection load='3oa1' size='340' side='right'caption='[[3oa1]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3oa1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rabies_virus_strain_Pasteur_vaccin Rabies virus strain Pasteur vaccin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OA1 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3oa1|  PDB=3oa1  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oa1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oa1 OCA], [https://pdbe.org/3oa1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oa1 RCSB], [https://www.ebi.ac.uk/pdbsum/3oa1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oa1 ProSAT]</span></td></tr>
+</table>
-===Crystal structure of phosphoprotein/Protein P/Protein M1 residues 69-297 from Rabies virus reveals degradation to C-terminal domain only===
+== Function ==
+[https://www.uniprot.org/uniprot/PHOSP_RABVP PHOSP_RABVP] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus. Might be involved, through interaction with host dynein, in intracellular microtubule-dependent virus transport of incoming virus from the synapse toward the cell body (By similarity).
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-OA1 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Rabies_virus_strain_pasteur_vaccin Rabies virus strain pasteur vaccin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OA1 OCA].
+Check<jmol>
-[[Category: Rabies virus strain pasteur vaccin]]
+  <jmolCheckbox>
-[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oa/3oa1_consurf.spt"</scriptWhenChecked>
-[[Category: Chaperone]]
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[Category: Phosphoprotein]]
+    <text>to colour the structure by Evolutionary Conservation</text>
-[[Category: Protein degredation]]
+  </jmolCheckbox>
-[[Category: Rabies virus]]
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3oa1 ConSurf].
-[[Category: Rabies virus protein n]]
+<div style="clear:both"></div>
-[[Category: Seattle structural genomics center for infectious disease]]
+__TOC__
-[[Category: Ssgcid]]
+</StructureSection>
+[[Category: Large Structures]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:51:47 2010''
+[[Category: Rabies virus strain Pasteur vaccin]]