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| [[Image:1ain.png|left|200px|thumb|Crystal Structure of Human Annexin I, [[1ain]]]] | | <StructureSection load='1n42' size='350' side='right' caption='Rat annexin V complex with Ca+2 (green) and sulfate (PDB code [[1n42]])' scene='41/410357/Cv/3'> |
| {{STRUCTURE_1ain| PDB=1ain | SIZE=300| SCENE= |right|CAPTION=Human Annexin I, [[1ain]] }}
| | __TOC__ |
| | == Function == |
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| '''3D Structure of Annexin''' | | [[Annexin|Annexins]] are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. Annexins divide into species and are numbered from I to XII. |
| | *'''Annexin I''' is involved in a variety of pathways<ref>PMID:17215481</ref>. <br /> |
| | *'''Annexin II''' is involved in angiogenesis, tutor progression and metastasis<ref>PMID:18220793</ref>. See also [[Ezetimibe]].<br /><br /> |
| | *'''Annexin V''' is the most abundant scaffolding protein. <br /> |
| | *'''Annexin VI''' is involved in endocytosis and regulates entry of ligands to prelysosomal compartment<ref>PMID:10940299</ref>. <br /> |
| | *'''Annexin VIII''' is calcium-dependent phospholipid-binding involved in blood coagulation<ref>PMID:8018923</ref>. <br /> |
| | *'''Annexin E1''' (AnE1) is associated with tubulin in trophozoites of ''Giardia lamblia'' and forms local slubs in the flagella. <br /> |
| | *'''Annexin A-V''' has a major role in coagulation. <br /> |
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| Annexins are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. They consist of 2 domains - the C-terminal core and the N-terminal head. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein.
| | == Relevance == |
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| == Annexin I ==
| | Annexin I is involved in anti-inflammatory responses and apoptotic mechanisms. |
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| | == Structural highlights == |
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| [[2q4c]], [[1ycn]] - AnI - Arabidopsis thaliana<br />
| | Annexins consist of 2 domains - the C-terminal core and the N-terminal head. The <scene name='41/410357/Cv/9'>core domain consists of 4 annexin repeats</scene> containing <scene name='41/410357/Cv/10'>5 helices</scene>. The core domain concave side contains the <scene name='41/410357/Cv/11'>Ca+2 binding sites</scene>.<ref>PMID:12401794</ref> |
| [[1mcx]], [[1hm6]] - pAnI - pig<br />
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| [[1qls]] - pAnI head+calgizzarrin<br />
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| [[1bo9]] - hAnI head - human NMR<br />
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| [[1ain]] - hAnI<br />
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| | ==3D structures of annexin== |
| | [[Annexin 3D structures]] |
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| == Annexin II ==
| | </StructureSection> |
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| [[2hyu]], [[2hyv]] - hAnII+heparin oligosaccharide<br />
| | == References == |
| [[2hyw]], [[1xjl]] - hAnII+Ca<br />
| | <references/> |
| [[1w7b]] - hAnII<br />
| | [[Category:Topic Page]] |
| [[1bt6]] - hAnII head+calpactin light chain<br />
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| == Annexin III ==
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| [[1aii]], [[1axn]] - hAnIII<br />
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| == Annexin IV ==
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| [[2zhi]], [[2zhj]], rAnIV+Na - rat<br />
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| [[2zoc]] - hAnIV<br />
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| [[1i4a]] - cAnIV (mutant) - cow<br />
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| [[1aow]], [[1ann]] - cAnIV<br />
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| == Annexin V ==
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| [[2ie6]], [[2ie7]], rAnV<br />
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| [[1n41]], [[1n42]], [[1n44]], [[2h0k]], [[2h0l]], [[2h0m]], [[1bc0]], [[1bc1]], [[1bc3]], [[1bcw]], [[1bcy]], [[1bcz]] - rAnV (mutant)<br />
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| [[1g5n]] - rAnV+ heparin oligosaccharide<br />
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| [[1a8a]], [[1a8b]] - rAnV+phospholipid analog<br />
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| [[2ran]] - rAnV+Ca<br />
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| [[2yii]] - chAnV+Ca - chicken<br />
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| [[1yj0]] - chAnV+Zn<br />
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| [[1ala]] - ChAnV<br />
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| [[1hak]] - hAnV+K-201<br />
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| [[1sav]] - hAnV (thioproline)<br />
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| [[1hvd]], [[1hve]], [[1hvf]], [[1hvg]] - hAnV (mutant)<br />
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| [[1anw]], [[1avh]], [[1avr]] - hAnV<br />
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| [[1anx]] - hAnV+Ca<br />
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| == Annexin VI == | |
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| [[1m9i]] - hAnVI (mutant)<br />
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| [[1avc]] - cAnVI+Ca<br /> | |
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| == Annexin VIII ==
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| [[1w3w]] - hAnVIII<br />
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| [[1w45]] - hAnVIII (mutant)<br />
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| == Annexin XII ==
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| [[1dm5]] - HvAnXII (mutant) - Hydra vulgaris<br />
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| [[1aei]] - HvAnXII<br />
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| == Other annexins ==
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| [[1dk5]] - An24 - Capsicom annuum<br />
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| [[3brx]] - coAnGH1+Ca - cotton<br />
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| [[1n00]] - coAnGH1<br />
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