Villin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, David Canner, Jaime Prilusky, Joel L. Sussman

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-[[Image:2k6n.png|left|300px]]
+<StructureSection load='' size='340' side='right' caption='Human supervillin headpiece, [[2k6n]]' scene='Villin/Cv/1' >
+== Function ==
+* [[Villin]] (VIL) is an actin-binding protein.  It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.<br />
+*   '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin<ref>PMID:20309963</ref>.<br />
+*  '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.<br />
+*  '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton<ref>PMID:8089177</ref>.
-{{STRUCTURE_2k6n|  PDB=2k6n  |  SCENE= |CAPTION=Human Supervillin Headpiece, [[2k6n]] }}
+== Relevance ==
+VIL immunohisochemistry is a reliable method for diagnosing microvillus inclusion disease (MVID)<ref>PMID:25517957</ref>.
+</StructureSection>
+== 3D Structures of Villin ==
-'''3D Structure of Villin''' <br />
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-The image at the top is a human Human Supervillin Headpiece (3ffn)
+{{#tree:id=OrganizedByTopic|openlevels=0|
+* Supervillin
+**[[2k6m]], [[2k6n]] – hSVIL headpiece– human – NMR<br />
+* Villin
+**[[3fg7]] – hVIL-1 gelsolin domains 4-6<br />
+**[[1unc]] – hVIL-1 headpiece<br />
+**[[3iur]] - hVIL headpiece H2H3 helices + prolyl endopeptidase <br />
+**[[1yu5]], [[1qqv]] - cVIL headpiece - chicken<br />
+**[[2rjw]], [[2rjx]], [[2rjv]], [[2rjy]], [[1yu7]], [[1yu8]], [[3myc]], [[3mye]], [[3nkj]], [[3mya]], [[3tjw]], [[3trv]], [[3trw]], [[3try]] - cVIL-1 headpiece (mutant)<br />
+**[[2llf]] - cVIL-1 gelsolin-like domain 6 - NMR<br />
+**[[5i1n]], [[5i1o]], [[5i1p]], [[5i1s]] – cVIL-1 + cVIL headpiece<br />
+**[[1vii]], [[2vik]], [[2vil]], [[4cz3]], [[4cz4]] - cVIL-14T headpiece - NMR<br />
+**[[2ppz]], [[2jm0]] - VIL-1 headpiece (mutant) – synthetic – NMR<br />
+**[[2f4k]], [[1wy3]], [[1wy4]], [[1yrf]], [[1yri]] - VIL-1 fragment (mutant) – synthetic<br />
+**[[5vnt]] - VIL-4 C-terminal headpiece - ''Arabidopsis thaliana'' - NMR<br />
+* Advillin
+**[[1und]] – hAVIL headpiece<br />
+*Cytovillin or ezrin
+**[[1ni2]] – hCVIL  N terminal<br />
+**[[4rm8]], [[4rm9]] – hCVIL  <br />
+**[[4rma]] – hCVIL  FERM domain<br />
+}}
+==References==
+<references />
+[[Category:Topic Page]]