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==The hemagglutinin fusion peptide (H1 subtype) at pH 7.4== | |||
<StructureSection load='2kxa' size='340' side='right'caption='[[2kxa]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2kxa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/swine/Scotland/410440/94(H1N2)) Influenza A virus (A/swine/Scotland/410440/94(H1N2))]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KXA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kxa OCA], [https://pdbe.org/2kxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kxa RCSB], [https://www.ebi.ac.uk/pdbsum/2kxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kxa ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9YTC2_9INFA Q9YTC2_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00046902] | |||
__TOC__ | |||
</StructureSection> | |||
< | [[Category: Large Structures]] | ||
[[Category: Bax A]] | |||
[[Category: Lorieau JL]] | |||
[[Category: Louis JM]] | |||
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Latest revision as of 09:49, 1 May 2024
The hemagglutinin fusion peptide (H1 subtype) at pH 7.4The hemagglutinin fusion peptide (H1 subtype) at pH 7.4
Structural highlights
FunctionQ9YTC2_9INFA Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00046902] |
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