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[[Image:2xdg.jpg|left|200px]]


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==Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor.==
The line below this paragraph, containing "STRUCTURE_2xdg", creates the "Structure Box" on the page.
<StructureSection load='2xdg' size='340' side='right'caption='[[2xdg]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2xdg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDG FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_2xdg|  PDB=2xdg |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdg OCA], [https://pdbe.org/2xdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdg RCSB], [https://www.ebi.ac.uk/pdbsum/2xdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdg ProSAT]</span></td></tr>
 
</table>
===CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GROWTH HORMONE RELEASING HORMONE RECEPTOR.===
== Disease ==
 
[https://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN] Isolated growth hormone deficiency type IB. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:11232012</ref> <ref>PMID:10084571</ref> <ref>PMID:12534354</ref>
 
== Function ==
==About this Structure==
[https://www.uniprot.org/uniprot/GHRHR_HUMAN GHRHR_HUMAN] Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
2XDG is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDG OCA].  
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xdg ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Barr, A J.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Barr AJ]]
[[Category: Brown, N Burgess.]]
[[Category: Bountra C]]
[[Category: Carpenter, E P.]]
[[Category: Burgess Brown N]]
[[Category: Chaikuad, A.]]
[[Category: Carpenter EP]]
[[Category: Delft, F Von.]]
[[Category: Chaikuad A]]
[[Category: Edwards, A.]]
[[Category: Edwards A]]
[[Category: Muniz, J R.C.]]
[[Category: Muniz JRC]]
[[Category: Pike, A C.W.]]
[[Category: Pike ACW]]
[[Category: Quigley, A.]]
[[Category: Quigley A]]
[[Category: Shrestha, L.]]
[[Category: Shrestha L]]
[[Category: Vollmar, M.]]
[[Category: Vollmar M]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Yang, J.]]
[[Category: Yang J]]
[[Category: Membrane protein]]
[[Category: Von Delft F]]
[[Category: Receptor]]
[[Category: Signaling protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:36:12 2010''

Latest revision as of 11:04, 23 October 2024

Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor.Crystal structure of the extracellular domain of human growth hormone releasing hormone receptor.

Structural highlights

2xdg is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.95Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

GHRHR_HUMAN Isolated growth hormone deficiency type IB. The disease is caused by mutations affecting the gene represented in this entry.[1] [2] [3]

Function

GHRHR_HUMAN Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Salvatori R, Fan X, Phillips JA 3rd, Espigares-Martin R, Martin De Lara I, Freeman KL, Plotnick L, Al-Ashwal A, Levine MA. Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib. J Clin Endocrinol Metab. 2001 Jan;86(1):273-9. PMID:11232012
  2. ↑ Salvatori R, Hayashida CY, Aguiar-Oliveira MH, Phillips JA 3rd, Souza AH, Gondo RG, Toledo SP, Conceicao MM, Prince M, Maheshwari HG, Baumann G, Levine MA. Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene. J Clin Endocrinol Metab. 1999 Mar;84(3):917-23. PMID:10084571 doi:http://dx.doi.org/10.1210/jcem.84.3.5599
  3. ↑ Carakushansky M, Whatmore AJ, Clayton PE, Shalet SM, Gleeson HK, Price DA, Levine MA, Salvatori R. A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency. Eur J Endocrinol. 2003 Jan;148(1):25-30. PMID:12534354

2xdg, resolution 1.95Å

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