2ku4: Difference between revisions

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-{{Seed}}
-[[Image:2ku4.jpg|left|200px]]
-<!--
+==Horse prion protein==
-The line below this paragraph, containing "STRUCTURE_2ku4", creates the "Structure Box" on the page.
+<StructureSection load='2ku4' size='340' side='right'caption='[[2ku4]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2ku4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KU4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ku4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ku4 OCA], [https://pdbe.org/2ku4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ku4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ku4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ku4 ProSAT]</span></td></tr>
-{{STRUCTURE_2ku4|  PDB=2ku4  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/O97964_HORSE O97964_HORSE]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ku/2ku4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ku4 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The NMR structure of the horse (Equus caballus) cellular prion protein at 25 degrees C exhibits the typical PrP(C) [cellular form of prion protein (PrP)] global architecture, but in contrast to most other mammalian PrP(C)s, it contains a well-structured loop connecting the beta2 strand with the alpha2 helix. Comparison with designed variants of the mouse prion protein resulted in the identification of a single amino acid exchange within the loop, D167S, which correlates with the high structural order of this loop in the solution structure at 25 degrees C and is unique to the PrP sequences of equine species. The beta2-alpha2 loop and the alpha3 helix form a protein surface epitope that has been proposed to be the recognition area for a hypothetical chaperone, "protein X," which would promote conversion of PrP(C) into the disease-related scrapie form and thus mediate intermolecular interactions related to the transmission barrier for transmissible spongiform encephalopathies (TSEs) between different species. The present results are evaluated in light of recent indications from in vivo experiments that the local beta2-alpha2 loop structure affects the susceptibility of transgenic mice to TSEs and the fact that there are no reports on TSE in horses.
-===Horse prion protein===
+Horse prion protein NMR structure and comparisons with related variants of the mouse prion protein.,Perez DR, Damberger FF, Wuthrich K J Mol Biol. 2010 Jul 9;400(2):121-8. Epub 2010 May 8. PMID:20460128<ref>PMID:20460128</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2ku4" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20460128}}, adds the Publication Abstract to the page
+*[[Prion 3D structures|Prion 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20460128 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20460128}}
+__TOC__
+</StructureSection>
-==About this Structure==
-KU4 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KU4 OCA].
-==Reference==
-<ref group="xtra">PMID:20460128</ref><references group="xtra"/>
-[[Category: Equus caballus]]
-[[Category: Damberger, F F.]]
-[[Category: Perez, D R.]]
-[[Category: Wuthrich, K.]]
-[[Category: Amyloid]]
-[[Category: Cell membrane]]
-[[Category: Ecprp]]
 [[Category: Equus caballus]]
-[[Category: Horse]]
+[[Category: Large Structures]]
-[[Category: Membrane]]
+[[Category: Damberger FF]]
-[[Category: Membrane protein]]
+[[Category: Perez DR]]
-[[Category: Prion]]
+[[Category: Wuthrich K]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 11:05:34 2010''