3lxg: Difference between revisions

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-{{Seed}}
-[[Image:3lxg.jpg|left|200px]]
-<!--
+==Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3==
-The line below this paragraph, containing "STRUCTURE_3lxg", creates the "Structure Box" on the page.
+<StructureSection load='3lxg' size='340' side='right'caption='[[3lxg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3lxg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LXG FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=Z73:2-METHOXY-6,7-DIMETHYL-9-PROPYLIMIDAZO[1,5-A]PYRIDO[3,2-E]PYRAZINE'>Z73</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-{{STRUCTURE_3lxg|  PDB=3lxg  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lxg OCA], [https://pdbe.org/3lxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lxg RCSB], [https://www.ebi.ac.uk/pdbsum/3lxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lxg ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PDE10_RAT PDE10_RAT] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:10583409</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lx/3lxg_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lxg ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3===
+==See Also==
+*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-LXG is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LXG OCA].
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: Jestel, A.]]
+[[Category: Jestel A]]
-[[Category: Mosbacher, T.]]
+[[Category: Mosbacher T]]
-[[Category: Steinbacher, S.]]
+[[Category: Steinbacher S]]
-[[Category: Allosteric enzyme]]
-[[Category: Camp]]
-[[Category: Camp-binding]]
-[[Category: Catalytic domain]]
-[[Category: Cgmp]]
-[[Category: Cgmp-binding]]
-[[Category: Hydrolase]]
-[[Category: Metal-binding]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphodiesterase 10a]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:49:22 2010''