3kdf: Difference between revisions

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-{{Seed}}
-[[Image:3kdf.png|left|200px]]
-<!--
+==X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression==
-The line below this paragraph, containing "STRUCTURE_3kdf", creates the "Structure Box" on the page.
+<StructureSection load='3kdf' size='340' side='right'caption='[[3kdf]], [[Resolution|resolution]] 1.98&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3kdf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KDF FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.975&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_3kdf|  PDB=3kdf  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdf OCA], [https://pdbe.org/3kdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kdf RCSB], [https://www.ebi.ac.uk/pdbsum/3kdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kdf ProSAT]</span></td></tr>
+</table>
-===X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression===
+== Function ==
+[https://www.uniprot.org/uniprot/RFA3_HUMAN RFA3_HUMAN] Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>   Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-KDF is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDF OCA].
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/3kdf_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kdf ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Bingman, C A.]]
+[[Category: Large Structures]]
-[[Category: Burgie, E S.]]
+[[Category: Bingman CA]]
-[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
+[[Category: Burgie ES]]
-[[Category: Fox, B G.]]
+[[Category: Fox BG]]
-[[Category: Jr., G N.Phillips.]]
+[[Category: Makino S-I]]
-[[Category: Makino, S I.]]
+[[Category: Phillips Jr GN]]
-[[Category: Acetylation]]
-[[Category: Alternative splicing]]
-[[Category: Center for eukaryotic structural genomic]]
-[[Category: Cesg]]
-[[Category: Dna replication]]
-[[Category: Homo sapien]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Protein complex]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Replication]]
-[[Category: Replication protein some]]
-[[Category: Wheat germ cell free]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May  5 11:18:40 2010''