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User:Daniel Seeman/DELETE: Difference between revisions

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<applet load='Caspmorph.pdb' size='300' frame='true' align='right' caption='Toggle between active site inhibitor bound and allosterically inhibited caspase-7' />
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=== Forms of Caspase-7 ===
 
*<scene name='User:Daniel_Seeman/Caspase-7_Dynamics/1f1j/1'>Caspase-7 bound to dead-end substrate mimic DEVD-CHO</scene>, trapping protein in active/substrate bound conformation.
*<scene name='User:Daniel_Seeman/Caspase-7_Dynamics/1shj-234234/1'>Caspase-7 bound to allosteric inhibitor DICA through CYS290</scene> trapping protein in a form incompatible with substrate binding.
*<scene name='User:Daniel_Seeman/Caspase-7_Dynamics/Morph1/1'>Conformational change between substrate bound and substrate incompatible forms of Caspase-7</scene>
 
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Molecular Playground banner: Conformational Dynamics between active and allosterically inhibited caspase-7 elucidate the mechanism of allostery in this important class of cysteine proteases.
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