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A CBI Molecule being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst and on display at the Molecular Playground.
[[Image:YKL-40.jpg|frame|Crystal Structure of YKL-40]]
[[Image:YKL-40.jpg|frame|Crystal Structure of YKL-40]]


===YKL-40 is the best===
===YKL-40, a Secreted Glycoprotein===


YKL-40 is named for its first three amino acid residues--tyrosine, lysine, and leucine-- and its molecular weight, 40 kDa. It is a member of the chitinase family of proteins, although it has no chitinase activity. It has been implicated in the progession of inflammatory diseases, diabetes, and many cancers. It is one of the most up-regulated genes in glioblastoma multiform (GBM), the most common malignacy of the brain and central nervous system. High YKL-40 serum levels correlate with the worst prognosis for many cancers, especially in GBM. It is thought to increase tumor angiogenesis and endothelial cell migration into tumors.


{{STRUCTURE_1hjx |  PDB=1hjx  |  SCENE=  }}
{{STRUCTURE_1hjx |  PDB=1hjx  |  SCENE=  }}




{{Clear}}
Click here for a stick representation of the ligands bound to YKL-40 (Glycerol, N-ACETYL-D-GLUCOSAMINE, SULFATE ION):
<applet load='1hjx' size='[450,338]' frame='true' align='right'
<scene name='Ralph_A._Francescone_III/sandbox_1/Ligand_bound_state/1'>Ligand Bound State</scene>
caption='Crystal structure of human cartilage gp39 (1hjx)' scene='User:Ralph_A_Francescone_III/sandbox_1/Loadedfrompdb/4'/>


=== Ligand-binding domain ===
===References===


1.) Houston, D.R.,  Recklies, A.D.,  Krupa, J.C.,Van Aalten, D.M.F. Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes.(2003) J.Biol.Chem. 278: 30206.


The spinning protein (<scene name='User:Ralph_A_Francescone_III/sandbox_1/Loadedfrompdb/4'>Initial view</scene>) ) is the ligand binding domain of the aspartate receptor with the aspartate ligand bound (LKT).


 
2.) Shao et al. YKL-40, a secreted glycoprotein, promotes tumor angiogenesis. Oncogene (2009) 28, 4456–4468.
Molecular Playground banner: A receptor protein used by bacteria to "smell" their environment.

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Ralph A. Francescone III
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