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This guide to the contents of Proteopedia is maintained manually (not automatically generated) and so is inevitably incomplete. Please be sure to use the [[Help:Searching|search slots at the left]] if you don't find what you are looking for below.
This guide to the contents of Proteopedia is maintained manually (not automatically generated) and so is inevitably incomplete. Please be sure to use the [[Help:Searching|search slots at the left]] if you don't find what you are looking for below. Updated:  {{REVISIONDAY2}}-{{REVISIONMONTH}}-{{REVISIONYEAR}} (DD-MM-YYYY)


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'''When you create a new page in Proteopedia, please add it to corresponding topic subpages.'''
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* Introduction to Structural Biology
==Topics Pages Organized by Category==
** See [[About Macromolecular Structure]]
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** Water


*** [[Water in macromolecular models|Water in Macromolecular Models]]
* [[Introduction to protein structure]] - A introductory overview of protein structure.
** Key Chemical Concepts for Structural Biology
* [[About Macromolecular Structure]] - List of pages about macromolecular structure terms and concepts.
 
* [[Proteopedia:Topic Pages|Topic pages]] - List of pages about specific proteins or protein families.
*** [[Amino Acids]]
* [[Index pages]] - List of pages that list other pages within Proteopedia.
*** [[Cation-pi interactions]]
* Basics of Protein Structure
*** [[Hydrogen bond]]
**[[Introduction to protein structure]] - A introductory overview of protein structure
*** [[Hydrogen in macromolecular models|Hydrogen in Macromolecular Models]]
**[[Proteins: primary and secondary structure]]
*** [[Isoelectric point]]
**[[Myoglobin of Physeter catodon: structure]]
*** [[Salt bridges]]
** The Building Blocks
 
* Biomolecules
** [[About Macromolecular Structure]]
 
** Nucleotides, Nucleic Acids and Genetic Information
*** DNA
**** [[DNA]]
**** B-DNA [[1bna]]
**** [[Z-DNA]]
 
** Amino Acids
*** [[Amino Acids]]
*** [[Amino Acids]]
*** [[Selenocysteine]]
*** [[Backbone_representations]]
** Proteins, Primary Structure
*** [[Peptide]]
*** [[Conservation, Evolutionary]]
**** [[User:Stephen Mills/Peptide tutorial 1|Peptide tutorial 1 part 1]]
*** [[Isoelectric point]]
**** [[User:Stephen Mills/Peptide tutorial 2|Peptide tutorial 1 part 2]]
 
 
** Proteins, Three-Dimensional Structure
*** [[User:Tommie_Hata/Protein_Structure_Tutorial]]
*** [[S347/The four tiers of protein structure]]
*** [[Secondary structure]]
*** Protein structural motifs
**** [[User:James D Watson/Structural Templates]]
*** Fibrous Proteins
**** [[Coiled coil]]
**** [[Collagen]]
*** Protein Misfolding
**** [[Prion protein]]
**** [[A Physical Model of the Structure of GNNQQNY from Yeast Prion Sup35]]


** Colored Proteins & those that Change Color
** Conformational flexibility of a polypeptide chain
*** [[Green Fluorescent Protein]]; [[GFP (Hebrew)]]
*** [[Phi and Psi Angles]]
*** [[Dronpa]]
*** [[Ramachandran Plots]]
*** [[Factor IX]]
*** [[Tutorial:Ramachandran principle and phi psi angles]]
** [[Secondary structure]]
*** [[Helices in Proteins]]
**** [[User:Stephen Mills/Secondary Structure: Helices|Secondary Structure tutorial - Helices]]
*** [[Sheets in Proteins]]
**** [[User:Stephen Mills/Secondary Structure: Sheets|Secondary Structure tutorial - Sheets]]
** [[Structural_templates]]
*** [[Globular_Proteins]]
**** [[Turns in Proteins]]
*** [[Fibrous Proteins]]
**** [[Coiled_coil]]
**** [[Collagen]] - Illustrates the structure of a collagen segment as well as the structure of a mutated tropocollagen.
**** [[Fibroins]]


** DNA Binding Proteins
*** [[Helix-turn-helix motif]]
*** [[DNA-binding protein VirE2 from Agrobacterium tumefaciens complexed with chaperone VirE1]]


** Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies
** [[Unusual Motifs in Proteins]]
*** Antibodies
*** [[Cation-pi_interactions]]
**** [[IgA]]
*** [[Thermal_motion_of_peptide]]
**** [[Epitopes]]
**** [[Major Histocompatibility Complex Class I]]
*** [[Calmodulin in motion]]
*** [[Myoglobin]]
*** [[Hemoglobin]]; [[Hemoglobin (Hebrew)]]
*** [[Kinesin-5]]
** Lipids and Biological Membranes
** Lipid Binding Proteins
*** [[CRABP I ( Cellular Retinoic Acid Binding Protein )]]
** Membrane Transport Proteins
*** [[A Physical Model of the β2-Adrenergic Receptor]]
*** [[Lactose Permease]]
*** [[Proton Channels]]
*** [[Ion channels]]
**** [[M2 Proton Channel]]
**** [[Voltage-gated calcium channels]]
*** [[Mechanosensitive channels: opening and closing]]
***[[Enzyme I of the Phosphoenolpyruvate:Sugar Phosphotransferase System]]


** Prions and Intrinsically Disordered Proteins
** [[Intrinsically Disordered Protein]]
*** [[Prion protein]]
*** [[Doppel]]
*** [[Intrinsically Disordered Protein]]


** Toxins
* Carbohydrates
*** [[Insecticidal delta-endotoxin Cyt2Ba from Bacillus thuringiensis]]
**[[Carbohydrates]]
**[[Carbohydrates II]]
* Cytoskeletal Proteins
** [[Actin]]
** [[Keratins]]
** [[Tropomyosin]]
** [[Tubulin]]


** Mitosis, Meiosis and Cargo Transport Proteins
* Lipids
*** [[Kinesin-5]]
**[[Lipids: structure and classification]]


** Viruses
* Diseases & Related Topics
*** [[User:Wayne Decatur/Suppression of RNA Silencing by Viruses]]
** [[Alzheimer's Disease]]
*** Filamentous bacteriphage
** [[Antibody]]
**** [[G3p]] - minor coat protein found on the surface of filamentous bacteriophage
** [[Bacterial Infections]]
*** HIV
** [[Cancer]]
**** [[HIV-1 protease]]
** [[Coronavirus Disease 2019 (COVID-19)]]
**** [[HIV-1 Gag]]
** [[Diabetes & Hypoglycemia]]
**** [[HIV-1 Gag Recruitment of Tsg101 and the Viral Budding Process]]
** [[Hemophilia]]
**** [[User:Eric Martz/Molecular Playground/HIVDrug]]
** [[HIV]]
*** Herpes Simplex Virus
** [[Hypertension & Congestive Heart Failure]]
**** [[Herpes Simplex Virus Thymidine Kinase]]
** [[Immune Response]]
*** Influenza
** [[Inflammation & Rheumatoid Arthritis]]
**** [[Influenza hemagglutinin]]
** [[Influenza]]
**** [[Avian Influenza Neuraminidase, Tamiflu and Relenza]]
** [[Metabolic Disorders]]
** [[Neurodevelopmental Disorders]]
** [[Oncogenes]]
** [[Pharmaceutical Drugs]]
** [[Pharmaceutical Drug Targets]]
** [[Toxins]]
** [[Viral Infections]]


* Enzymes
* Enzymes
** Enzymatic Catalysis
** [[Hydrolases]]
*** Acid-beta-glucosidase
** [[Isomerases]]
**** reHuman Acid-beta-glucosidase made in CHO cells [[1ogs]]
** [[Ligases]]
**** reHuman Acid-beta-glucosidase made in CHO cells bound to conduritol B epoxide [[1y7v]]
** [[Lyases]]
**** reHuman Acid-beta-glucosidase made in carrot cells complexed with N-butyl-deoxynojirimycin [[2v3d]]
** [[Oxidoreductases]]
**** Velaglucerase Alfa [[2wkl]]
** [[Transferases]]
*** Acid Proteases
**** [[HIV-1 protease]]


**** [[Streptomyces griseus Aminopeptidase (SGAP)]]; [[Aminopeptidase]]
* Gene Expression & Replication
*** [[Aconitase]]
** [[DNA Replication]]
*** Cysteine Proteases
** [[Nucleic Acids]]
*** [[Hen Egg-White (HEW) Lysozyme]]
** [[Regulation of Gene Expression]]
*** [[Choline Oxidase]]
** [[RNAi]]
*** [[Enzyme I of the Phosphoenolpyruvate:Sugar Phosphotransferase System]]
** [[Transcription & RNA Processing]]
*** [[Metalloproteases]]
** [[Translation]]  
**** [[Matrix metalloproteinases]]
*** Oxidoreductases
**** [[NADH quinone oxidoreductase ]]
*** [[Phosphofructokinase %28PFK%29]]
*** [[Pyruvate phosphate dikinase]]
*** [[Serotonin N-acetyltransferase]]
*** Serine Hydrolases
**** [[Acetylcholinesterase]] (AChE)
***** [[Acetylcholine]]
***** [[Flexibility of aromatic residues in acetylcholinesterase]]
***** [[AChE inhibitors and substrates]]
****** [[1eve]] AChE-Aricept complex; [[1eve (Arabic)]]; [[1eve (Chinese)]]; [[1eve (Italian)]]; [[1eve (Russian)]]; [[1eve (Spanish)]]; [[1eve (Turkish)]]
****** [[AChE bivalent inhibitors]]
**** [[Tobacco Etch Virus (TEV) Protease]]
*** [[Serine Protease]]
**** [[Trypsin]]
*** [[Triose Phosphate Isomerase]]
** Enzyme Inhibitors
*** [[Alpha-1-antitrypsin]]
** Enzyme Kinetics, Inhibition, and Control
***[[Avian Influenza Neuraminidase, Tamiflu and Relenza]]
** Biochemical Signaling
*** [[Nitric oxide synthase]], [[NOS structures]]
*** [[Recoverin, a calcium-activated myristoyl switch]]
*** [[Bcl-2]]
*** [[C-Myc]]
*** [[C-di-GMP signaling]]
 
** Enzymes - Molecular Machines
*** [[Enzyme I of the Phosphoenolpyruvate:Sugar Phosphotransferase System]]
*** [[Pyruvate phosphate dikinase]]


* Large Macromolecular Assemblies
** [[Group:MUZIC|Muscle sarcomere: Z-Disk]]
** [[Ribosome]]
** [[Ribosoma 70S]]
** [[Nucleosomes]]
** [[Nucleosome structure]]


* Metabolism
* Metabolism
** Introduction to Metabolism
** [[Amino Acid Synthesis & Metabolism]]
** [[Carbohydrate Metabolism]]
** [[Photosynthesis]]
** [[Regulation of Gene Expression]]
** [[Drug Metabolism by CYP450 Enzymes]]


** Glucose Catabolism
* Miscellaneous
*** [[Triose Phosphate Isomerase]]
** [[Colored & Bioluminescent Proteins]]
***[[Phosphofructokinase %28PFK%29]]
** [[Coronavirus Disease 2019 (COVID-19)]]
 
** [[Enzimas: complejo enzima-sustrato]]
 
** [[3D Molecular Models]]
** Glycogen Metabolism and Gluconeogenesis
*** [[Phosphoglucose isomerase]]
*** [[Calmodulin in motion]]
*** [[Biotin Protein Ligase]]


** Citric Acid Cycle
* Signaling & Transport
*** [[Aconitase]]
** [[Hormone]]
** [[Membrane Channels & Pumps]]


** Electron Transport and Oxidative Phosphorylation
*** [[NADH quinone oxidoreductase ]]
** Photosynthesis
*** [[Photosystem II]]
*** [[Ribulose-1,5-bisphosphate carboxylase/oxygenase]]
*** [[PrrA in Rhodobacter sphaeroides]]
*** [[Pyruvate phosphate dikinase]]
** Lipid Metabolism
*** [[Acid-beta-glucosidase]]
** Amino Acid Metabolism
*** [[Aromatic amino acid hydroxylases]]
*** [[Phenylalanine hydroxylase]]
*** [[Tyrosine hydroxylase]]
*** [[ATP Phosphoribosyl Transferase]]
*** [[Isochorismate pyruvate lyase]]
** Mammalian Fuel Metabolism: Integration and Regulation
** Nucleotide Metabolism
*** [[Dihydrofolate reductase]]
* Gene Expression and Replication
** Nucleic Acid Structure
*** [[DNA]]
**** B-DNA [[1bna]]
**** [[Z-DNA]]
*** [[Nucleosomes]]
** DNA Replication, Repair, and Recombination
*** [[DNA Replication,Transcription and Translation]]
*** [[DNA Polymerase I]]
*** [[PcrA helicase]]
*** [[Fpg Nei Protein Superfamily]] - DNA Repair and Base Excision DNA Repair
*** [[Human RecQ-Like protein 1]] - RecQ family of DNA helicases are conserved in from bacteria to man
*** [[Structure of E. coli DnaC helicase loader]]
***[[1x9n#Crystal Structure of Human DNA Ligase I bound to 5.27-adenylated.2C nicked DNA]]
*** [[Rop protein]]
** Transcription and RNA Processing
*** [[C-Myc]]
*** [[Lac repressor]]
*** [[Reverse transcriptase]]
*** [[TATA-Binding Protein]]
*** [[RSP1275]]
*** [[Transcription Termination Factor Rho]]
** Protein Synthesis
*** [[Ribosome]]
*** [[SelB Recognition]]
** Regulation of Gene Expression
*** [[Lac repressor]]
*** [[Irr]] (Iron Response Regulator )
*** Oncogenes
**** [[P53]]
**** [[SRC]]
*** [[Tangible Models of Cdc42 Interacting With Intersectin]]
* Evolution
** [[Conservation, Evolutionary]]
** [[Extremophiles]]
* Immune System
** Antibodies
*** [[IgA]]
*** [[Epitopes]]
** [[Major Histocompatibility Complex Class I]]
*** [[Human beta two microglobulin]]
* Diseases
** Cancer
*** [[SRC]]
*** [[Proteins involved in cancer]]
* Methods of Structure Determination
** X-ray
*** [[X-ray crystallography]]
**** [[Asymmetric Unit]]
**** [[Biological Unit]]
**** [[Electron density maps]]
*** SAXS
**  NMR
*** [[NMR Ensembles of Models]]
** Electron Microscopy
* Methods of Structure & Sequence Analysis
** Structural Analysis & Visualization
*** [[CPK]] - Corey-Pauling-Koltun spacefilling molecular models and color scheme for elements
*** [[Chime]]
*** Jmol
**** [[S347/Visualising protein structure|Visualising Protein Structure]] - Introduction to Jmol
**** [[FirstGlance in Jmol]]
*** [[User:Wayne Decatur/Teaching Proteopedia|Teaching Proteopedia]]
*** [[User:Wayne Decatur/Generate Unfolded Structures|Generate Unfolded Structures]]
*** Homology Model
**** [[User:Wayne Decatur/Homology Modeling|Homology Modeling]]
**** [[User:Emi Nakayama/TRIM5a Homology Models|TRIM5a Homology Models]] - Differences in models as a function of their templates
*** [[DRuMS]] - set of standard color schemes for macromolecular visualization
** Sequence Analysis
*** [[User:Wayne Decatur/Sequence analysis tools|Sequence Analysis Tools]]
* Model Structures
** See [[Theoretical models]]
** [[African Malaria Mosquito Acetylcholinesterase]]
** [[Structure of E. coli DnaC helicase loader]]
** [[User:Yuan-Ping Pang/HAB•BoNTAe]]
* Miscellaneous
** [[Molecular Playground]]
** [[Research Groups]]
}}
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