Michael nobbe sandbox 1: Difference between revisions
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== '''Structure:'''== | == '''Structure:'''== | ||
Isocitrate dehydrogenase is SCOP classified as an alpha beta structure. Its secondary composition consists of mainly alpha helices and beta sheets which are arranged into three layer alpha beta alpha sandwich structures. The entire protein consists of two side by side sandwich structures that face opposite directions. This then causes the proteins two active sites to face opposite directions | Isocitrate dehydrogenase is SCOP classified as an alpha beta structure. Its secondary composition consists of mainly alpha helices and beta sheets which are arranged into three layer alpha beta alpha sandwich structures. The entire protein consists of two side by side sandwich structures that face opposite directions. This then causes the proteins two active sites to face opposite directions. These two groups make up the A and B subunits of isocitrate dehydrogenase. | ||
[[Image:Human isocitrate.jpg]] | [[Image:Human isocitrate.jpg]] [[Image:Chemicals isocitrate.jpg]] | ||
Human Isocitrate Dehydrogenase bound by NADH and CA2+ | Human Isocitrate Dehydrogenase bound by NADH and CA2+ Citric Acid is converted to alpha-ketoglutarate | ||
and Citrate Image made using JMOL | |||
Image from: http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase | |||
Citric Acid is converted to alpha-ketoglutarate | |||
Image from: http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase | |||
== '''Function:'''== | == '''Function:'''== | ||