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==Crystal structure of porcine heart mitochondrial complex II bound with Atpenin A5== | |||
<StructureSection load='3aee' size='340' side='right'caption='[[3aee]], [[Resolution|resolution]] 3.22Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3aee]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AEE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AT5:3-[(2S,4S,5R)-5,6-DICHLORO-2,4-DIMETHYL-1-OXOHEXYL]-4-HYDROXY-5,6-DIMETHOXY-2(1H)-PYRIDINONE'>AT5</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aee OCA], [https://pdbe.org/3aee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aee RCSB], [https://www.ebi.ac.uk/pdbsum/3aee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aee ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SDHA_PIG SDHA_PIG] Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor (By similarity). | |||
==See Also== | |||
*[[Succinate dehydrogenase 3D structures|Succinate dehydrogenase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sus scrofa]] | |||
[[Category: Harada S]] | |||
[[Category: Honma T]] | |||
[[Category: Inaoka DK]] | |||
[[Category: Inoue M]] | |||
[[Category: Kido Y]] | |||
[[Category: Kita K]] | |||
[[Category: Mao J]] | |||
[[Category: Matsuoka S]] | |||
[[Category: Omori J]] | |||
[[Category: Osanai A]] | |||
[[Category: Sakamoto K]] | |||
[[Category: Sasaki T]] | |||
[[Category: Shindo M]] | |||
[[Category: Tanaka A]] | |||
Latest revision as of 13:31, 27 September 2023
Crystal structure of porcine heart mitochondrial complex II bound with Atpenin A5Crystal structure of porcine heart mitochondrial complex II bound with Atpenin A5
Structural highlights
FunctionSDHA_PIG Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor (By similarity). See Also |
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