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==Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-methyl-benzamide== | |||
<StructureSection load='3ae4' size='340' side='right'caption='[[3ae4]], [[Resolution|resolution]] 2.91Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ae4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AE4 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.91Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=N1M:2-IODO-N-METHYLBENZAMIDE'>N1M</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ae4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ae4 OCA], [https://pdbe.org/3ae4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ae4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ae4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ae4 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SDHA_PIG SDHA_PIG] Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor (By similarity). | |||
==See Also== | |||
*[[Succinate dehydrogenase 3D structures|Succinate dehydrogenase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sus scrofa]] | |||
[[Category: Harada S]] | |||
[[Category: Honma T]] | |||
[[Category: Inaoka DK]] | |||
[[Category: Inoue M]] | |||
[[Category: Kido Y]] | |||
[[Category: Kita K]] | |||
[[Category: Mao J]] | |||
[[Category: Matsuoka S]] | |||
[[Category: Omori J]] | |||
[[Category: Osanai A]] | |||
[[Category: Sakamoto K]] | |||
[[Category: Sasaki T]] | |||
[[Category: Shindo M]] | |||
[[Category: Tanaka A]] | |||
Latest revision as of 11:44, 30 October 2024
Crystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-methyl-benzamideCrystal structure of porcine heart mitochondrial complex II bound with 2-Iodo-N-methyl-benzamide
Structural highlights
FunctionSDHA_PIG Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor (By similarity). See Also |
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