2kt1: Difference between revisions

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-{{Seed}}
-[[Image:2kt1.png|left|200px]]
-<!--
+==Solution NMR Structure of the SH3 Domain from the p85beta subunit of Phosphatidylinositol 3-kinase from H.sapiens, Northeast Structural Genomics Consortium Target HR5531E==
-The line below this paragraph, containing "STRUCTURE_2kt1", creates the "Structure Box" on the page.
+<StructureSection load='2kt1' size='340' side='right'caption='[[2kt1]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2kt1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KT1 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kt1 OCA], [https://pdbe.org/2kt1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kt1 RCSB], [https://www.ebi.ac.uk/pdbsum/2kt1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kt1 ProSAT]</span></td></tr>
-{{STRUCTURE_2kt1|  PDB=2kt1  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/P85B_HUMAN P85B_HUMAN] Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/2kt1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kt1 ConSurf].
+<div style="clear:both"></div>
-===Solution NMR Structure of the SH3 Domain from the p85beta subunit of Phosphatidylinositol 3-kinase from H.sapiens, Northeast Structural Genomics Consortium Target HR5531E===
+==See Also==
+*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-KT1 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KT1 OCA].
 [[Category: Homo sapiens]]
-[[Category: Aramini, J M.]]
+[[Category: Large Structures]]
-[[Category: Everett, J K.]]
+[[Category: Aramini JM]]
-[[Category: Ma, L.]]
+[[Category: Everett JK]]
-[[Category: Montelione, G T.]]
+[[Category: Ma L]]
-[[Category: NESG, Northeast Structural Genomics Consortium.]]
+[[Category: Montelione GT]]
-[[Category: Schauder, C.]]
+[[Category: Schauder C]]
-[[Category: P85beta subunit of pi3k]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Protein structure initiative]]
-[[Category: Psi-2]]
-[[Category: Sh3 domain]]
-[[Category: Structural genomic]]
-[[Category: Target hr5531e]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb  3 08:54:49 2010''