3kox: Difference between revisions

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[[Image:3kox.jpg|left|200px]]


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==Crystal Structure of ornithine 4,5 aminomutase in complex with 2,4-diaminobutyrate (Anaerobic)==
The line below this paragraph, containing "STRUCTURE_3kox", creates the "Structure Box" on the page.
<StructureSection load='3kox' size='340' side='right'caption='[[3kox]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3kox]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Acetoanaerobium_sticklandii Acetoanaerobium sticklandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KOX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5AD:5-DEOXYADENOSINE'>5AD</scene>, <scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=Z98:(2S)-2-AMINO-4-{[(1Z)-{3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYLIDENE]AMINO}BUTANOIC+ACID'>Z98</scene></td></tr>
{{STRUCTURE_3kox| PDB=3kox |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kox FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kox OCA], [https://pdbe.org/3kox PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kox RCSB], [https://www.ebi.ac.uk/pdbsum/3kox PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kox ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OAME_ACESD OAME_ACESD] Component of a complex that catalyzes the reversible migration of the omega amino group of D-ornithine to C-4 to form (2R,4S)-2,4-diaminopentanoic acid. OraE may be the catalytic subunit. Active only on D-ornithine and 2,4-diaminopentanoic acid but not active on L-ornithine, L-beta-lysine, L-alpha-lysine or D-alpha-lysine.<ref>PMID:11577113</ref> <ref>PMID:4711468</ref> <ref>PMID:4711468</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/3kox_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kox ConSurf].
<div style="clear:both"></div>


===Crystal Structure of ornithine 4,5 aminomutase in complex with 2,4-diaminobutyrate (Anaerobic)===
==See Also==
 
*[[Aminomutase 3D structures|Aminomutase 3D structures]]
 
== References ==
==About this Structure==
<references/>
3KOX is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Clostridium_sticklandii Clostridium sticklandii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KOX OCA].
__TOC__
[[Category: Clostridium sticklandii]]
</StructureSection>
[[Category: Levy, C W.]]
[[Category: Acetoanaerobium sticklandii]]
[[Category: Leys, D.]]
[[Category: Large Structures]]
[[Category: Scrutton, N S.]]
[[Category: Levy CW]]
[[Category: Wolthers, K R.]]
[[Category: Leys D]]
[[Category: Anaerobic]]
[[Category: Scrutton NS]]
[[Category: D-ornithine 4]]
[[Category: Wolthers KR]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 20:03:42 2010''

Latest revision as of 13:17, 21 February 2024

Crystal Structure of ornithine 4,5 aminomutase in complex with 2,4-diaminobutyrate (Anaerobic)Crystal Structure of ornithine 4,5 aminomutase in complex with 2,4-diaminobutyrate (Anaerobic)

Structural highlights

3kox is a 8 chain structure with sequence from Acetoanaerobium sticklandii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OAME_ACESD Component of a complex that catalyzes the reversible migration of the omega amino group of D-ornithine to C-4 to form (2R,4S)-2,4-diaminopentanoic acid. OraE may be the catalytic subunit. Active only on D-ornithine and 2,4-diaminopentanoic acid but not active on L-ornithine, L-beta-lysine, L-alpha-lysine or D-alpha-lysine.[1] [2] [3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Chen HP, Wu SH, Lin YL, Chen CM, Tsay SS. Cloning, sequencing, heterologous expression, purification, and characterization of adenosylcobalamin-dependent D-ornithine aminomutase from Clostridium sticklandii. J Biol Chem. 2001 Nov 30;276(48):44744-50. Epub 2001 Sep 27. PMID:11577113 doi:http://dx.doi.org/10.1074/jbc.M108365200
  2. ↑ Somack R, Costilow RN. Purification and properties of a pyridoxal phosphate and coenzyme B 12 dependent D- -ornithine 5,4-aminomutase. Biochemistry. 1973 Jul 3;12(14):2597-604. PMID:4711468
  3. ↑ Somack R, Costilow RN. Purification and properties of a pyridoxal phosphate and coenzyme B 12 dependent D- -ornithine 5,4-aminomutase. Biochemistry. 1973 Jul 3;12(14):2597-604. PMID:4711468

3kox, resolution 2.40Å

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