3crh: Difference between revisions

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-{{Seed}}
-[[Image:3crh.png|left|200px]]
-<!--
+==Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala==
-The line below this paragraph, containing "STRUCTURE_3crh", creates the "Structure Box" on the page.
+<StructureSection load='3crh' size='340' side='right'caption='[[3crh]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3crh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CRH FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3crh|  PDB=3crh  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3crh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3crh OCA], [https://pdbe.org/3crh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3crh RCSB], [https://www.ebi.ac.uk/pdbsum/3crh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3crh ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/FGF1_HUMAN FGF1_HUMAN] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro.<ref>PMID:8663044</ref> <ref>PMID:16597617</ref> <ref>PMID:20145243</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/3crh_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3crh ConSurf].
+<div style="clear:both"></div>
-===Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala===
+==See Also==
+*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_19923735}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 19923735 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_19923735}}
-==About this Structure==
-CRH is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRH OCA].
-==Reference==
-<ref group="xtra">PMID:19923735</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Blaber, M.]]
+[[Category: Large Structures]]
-[[Category: Honjo, E.]]
+[[Category: Blaber M]]
-[[Category: Kuroki, R.]]
+[[Category: Honjo E]]
-[[Category: Lee, J.]]
+[[Category: Kuroki R]]
-[[Category: Meher, A K.]]
+[[Category: Lee J]]
-[[Category: Somasundaram, T.]]
+[[Category: Meher AK]]
-[[Category: Acetylation]]
+[[Category: Somasundaram T]]
-[[Category: Angiogenesis]]
-[[Category: Crystal packing]]
-[[Category: Developmental protein]]
-[[Category: Differentiation]]
-[[Category: Growth factor]]
-[[Category: Heparin-binding]]
-[[Category: Hormone]]
-[[Category: Mitogen]]
-[[Category: Polymorphism]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan  6 09:03:49 2010''