1gxl: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
New page: left|200px<br /><applet load="1gxl" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gxl, resolution 3.0Å" /> '''SMC HINGE DOMAIN FROM...
 
No edit summary
 
(15 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:1gxl.gif|left|200px]]<br /><applet load="1gxl" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1gxl, resolution 3.0&Aring;" />
'''SMC HINGE DOMAIN FROM T. MARITIMA WITH COILED COIL'''<br />


==Overview==
==SMC hinge domain from T. maritima with coiled coil==
Sister chromatids are held together by the multisubunit cohesin complex, which contains two SMC (Smc1 and Smc3) and two non-SMC (Scc1 and Scc3), proteins. The crystal structure of a bacterial SMC "hinge" region along, with EM studies and biochemical experiments on yeast Smc1 and Smc3, proteins show that SMC protamers fold up individually into rod-shaped, molecules. A 45 nm long intramolecular coiled coil separates the hinge, region from the ATPase-containing "head" domain. Smc1 and Smc3 bind to, each other via heterotypic interactions between their hinges to form a, V-shaped heterodimer. The two heads of the V-shaped dimer are connected by, different ends of the cleavable Scc1 subunit. Cohesin therefore forms a, large proteinaceous loop within which sister chromatids might be entrapped, after DNA replication.
<StructureSection load='1gxl' size='340' side='right'caption='[[1gxl]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1gxl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GXL FirstGlance]. <br>
1GXL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GXL OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gxl OCA], [https://pdbe.org/1gxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gxl RCSB], [https://www.ebi.ac.uk/pdbsum/1gxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gxl ProSAT]</span></td></tr>
==Reference==
</table>
Molecular architecture of SMC proteins and the yeast cohesin complex., Haering CH, Lowe J, Hochwagen A, Nasmyth K, Mol Cell. 2002 Apr;9(4):773-88. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11983169 11983169]
== Function ==
[[Category: Single protein]]
[https://www.uniprot.org/uniprot/Q9X0R4_THEMA Q9X0R4_THEMA] Required for chromosome condensation and partitioning.[HAMAP-Rule:MF_01894]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gx/1gxl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gxl ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Haering, C.]]
[[Category: Haering C]]
[[Category: Lowe, J.]]
[[Category: Lowe J]]
[[Category: Nasmyth, K.]]
[[Category: Nasmyth K]]
[[Category: anti parallel coiled coil]]
[[Category: smc dimerisation domain]]
[[Category: smc proteins]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:56:18 2007''

Latest revision as of 14:25, 27 March 2024

SMC hinge domain from T. maritima with coiled coilSMC hinge domain from T. maritima with coiled coil

Structural highlights

1gxl is a 4 chain structure with sequence from Thermotoga maritima. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q9X0R4_THEMA Required for chromosome condensation and partitioning.[HAMAP-Rule:MF_01894]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

1gxl, resolution 3.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1gxl&oldid=4114740"