Sandbox21: Difference between revisions

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-==Trypsin==
 '''This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks!
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 by Kevin Chen 3-3-09
+==Trypsin==
+Trypsin is an enzyme that breaks down protein, that is produced in the pancreas and then secreted in to the small intestines. It is a homolog of chymotrypsin and it works by cleaving at the peptide bond after residues with long, positively charged side chains. An aspartate residue which attracts and stabilizes a positively charged arginine or lysine residue in the substrate. The disease of cystic fibrosis is the result of deficiency in transport of trypsin and other digestive enzymes from the pancreas.
+==Structure==
+This is the protein Trypsin,it has <scene name='Sandbox21/Trypsin_alpha_helix/1'>alpha helices</scene> (shown in red) and also <scene name='Sandbox21/Trypsin_beta_sheets/1'>beta sheets</scene> (shown in blue), also the <scene name='Sandbox21/Trypsin_hydrophobic/1'>amphipathic</scene> parts of Trypsin are found throught out the molecule. Image of the crystal complex between bovine trypsin and Veronica Hederfolia trypsin found at [[2cmy]].
 {{STRUCTURE_2cmy |  PDB=2cmy  |  SCENE=  }}
-This is the protein Trypsin,it has <scene name='Sandbox21/Trypsin_alpha_helix/1'>alpha helices</scene> (shown in red) and also <scene name='Sandbox21/Trypsin_beta_sheets/1'>beta sheets</scene> (shown in blue), now the <scene name='Sandbox21/Trypsin_hydrophobic/1'>hydrophobic</scene> parts of Trypsin are on both the surface and inside.
+Reference-
-Trypsin is an enzyme that breaks down protein, that is produced in the pancreas and then secreted in to the small intestines. The disease of cystic fibrosis is the result of deficiency in transport of trypsin and other digestive enzymes from the pancreas.
+Berg, Tymoczko, Stryer, Biochemistry 6th ed. W.H. Freeman and CO.