Sandbox315: Difference between revisions
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This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! | This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! Juna Jovani | ||
==Macrophage Elastase== | ==Macrophage Elastase== | ||
Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. | Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a <scene name='Sandbox315/1jk3_hydrophobic/1'>hydrophobic</scene> active-site cleft. The red structures indicate where the hydrophobic residues are located. The enzyme has two <scene name='Sandbox315/Beta_sheet/1'>beta sheets</scene> shown in purple. | ||
Reference[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-457CY1P-6G&_user=1516330&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000053443&_version=1&_urlVersion=0&_userid=1516330&md5=374e1e8bd2911c09295d019540f42bca] | |||
{{STRUCTURE_1jk3 | PDB=1jk3 | SCENE= }} | {{STRUCTURE_1jk3 | PDB=1jk3 | SCENE= }} | ||
Latest revision as of 19:46, 4 March 2009
This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! Juna Jovani
Macrophage ElastaseMacrophage Elastase
Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a active-site cleft. The red structures indicate where the hydrophobic residues are located. The enzyme has two shown in purple.
Reference[1]
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| 1jk3, resolution 1.09Å () | |||||||||
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| Ligands: | , , | ||||||||
| Activity: | Macrophage elastase, with EC number 3.4.24.65 | ||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
