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==Elastase== | This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! Juna Jovani | ||
==Macrophage Elastase== | |||
Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a <scene name='Sandbox315/1jk3_hydrophobic/1'>hydrophobic</scene> active-site cleft. The red structures indicate where the hydrophobic residues are located. The enzyme has two <scene name='Sandbox315/Beta_sheet/1'>beta sheets</scene> shown in purple. | |||
Reference[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-457CY1P-6G&_user=1516330&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000053443&_version=1&_urlVersion=0&_userid=1516330&md5=374e1e8bd2911c09295d019540f42bca] | |||
{{STRUCTURE_1jk3 | PDB=1jk3 | SCENE= }} | {{STRUCTURE_1jk3 | PDB=1jk3 | SCENE= }} |