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The collaborative, 3D encyclopedia of proteins and other molecules. | The collaborative, 3D encyclopedia of proteins and other molecules. | ||
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You've been redirected to a static version of the Main Page because you don't have Java. Java is required in order to view the 3D molecules in Proteopedia. Please download Java at http://www.java.com | |||
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===Green links change the 3D image!=== | ===Green links change the 3D image!=== | ||
<big>''Here's an excerpt from one of our pages:''</big> | <big>''Here's an excerpt from one of our pages:''</big> | ||
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The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <b><font color='green'>unique orientation</font></b> along the active-site gorge, extending from the anionic subsite (<b><font color='green'>W84</font></b>) of the active site, at the bottom, to the peripheral anionic site (<b><font color='green'>near W279</font></b>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <b><font color='green' >indirectly via solvent molecules</font></b>. | The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds acetylcholinesterase (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <b><font color='green'>unique orientation</font></b> along the active-site gorge, extending from the anionic subsite (<b><font color='green'>W84</font></b>) of the active site, at the bottom, to the peripheral anionic site (<b><font color='green'>near W279</font></b>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <b><font color='green' >indirectly via solvent molecules</font></b>. | ||
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You've been referred to this page because your computer is most likely missing Java. | You've been referred to this page because your computer is most likely missing Java. | ||
You will find in this [[Proteopedia:Troubleshooting|Troubleshooting]] page help for enabling Java in your computer and start enjoying Proteopedia's features. | You will find in this [[Proteopedia:Troubleshooting|Troubleshooting]] page help for enabling Java in your computer and start enjoying Proteopedia's features. | ||
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