9jup: Difference between revisions

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'''Unreleased structure'''


The entry 9jup is ON HOLD  until Paper Publication
==Structure of Arabidopsis thaliana ABCB1 with AMP-PNP bound in the outward-facing conformation==
 
<StructureSection load='9jup' size='340' side='right'caption='[[9jup]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9jup]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JUP FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jup OCA], [https://pdbe.org/9jup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jup RCSB], [https://www.ebi.ac.uk/pdbsum/9jup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jup ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AB1B_ARATH AB1B_ARATH] Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin, as well as the expression of genes in response to light. Participates directly in auxin efflux and thus regulates the polar (presumably basipetal) auxin transport (from root tips to root elongating zone). Transports also some auxin metabolites such as oxindoleacetic acid and indoleacetaldehyde. Involved in diverse auxin-mediated responses including gravitropism, phototropism and lateral root formation. Confers resistance to herbicides such as dicamba, pendimethalin, oryzalin, and monosodium acid methanearsonate (MSMA), but not to herbicides such as glyphosate, atrazine, bentazon and fluazifop-p-butyl. Mediates also resistance to xenobiotics such as cycloheximide and the cytokinin N6-(2-isopentenyl)adenine (2IP).<ref>PMID:10760241</ref> <ref>PMID:11701880</ref> <ref>PMID:12640467</ref> <ref>PMID:14517332</ref> <ref>PMID:15908594</ref> <ref>PMID:16212599</ref> <ref>PMID:9761790</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Chen Q]]

Latest revision as of 11:24, 5 March 2025

Structure of Arabidopsis thaliana ABCB1 with AMP-PNP bound in the outward-facing conformationStructure of Arabidopsis thaliana ABCB1 with AMP-PNP bound in the outward-facing conformation

Structural highlights

9jup is a 1 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AB1B_ARATH Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin, as well as the expression of genes in response to light. Participates directly in auxin efflux and thus regulates the polar (presumably basipetal) auxin transport (from root tips to root elongating zone). Transports also some auxin metabolites such as oxindoleacetic acid and indoleacetaldehyde. Involved in diverse auxin-mediated responses including gravitropism, phototropism and lateral root formation. Confers resistance to herbicides such as dicamba, pendimethalin, oryzalin, and monosodium acid methanearsonate (MSMA), but not to herbicides such as glyphosate, atrazine, bentazon and fluazifop-p-butyl. Mediates also resistance to xenobiotics such as cycloheximide and the cytokinin N6-(2-isopentenyl)adenine (2IP).[1] [2] [3] [4] [5] [6] [7]

References

  1. ↑ Thomas C, Rajagopal A, Windsor B, Dudler R, Lloyd A, Roux SJ. A role for ectophosphatase in xenobiotic resistance. Plant Cell. 2000 Apr;12(4):519-33. PMID:10760241 doi:10.1105/tpc.12.4.519
  2. ↑ Noh B, Murphy AS, Spalding EP. Multidrug resistance-like genes of Arabidopsis required for auxin transport and auxin-mediated development. Plant Cell. 2001 Nov;13(11):2441-54. PMID:11701880 doi:10.1105/tpc.010350
  3. ↑ Windsor B, Roux SJ, Lloyd A. Multiherbicide tolerance conferred by AtPgp1 and apyrase overexpression in Arabidopsis thaliana. Nat Biotechnol. 2003 Apr;21(4):428-33. PMID:12640467 doi:10.1038/nbt809
  4. ↑ Geisler M, Kolukisaoglu HU, Bouchard R, Billion K, Berger J, Saal B, Frangne N, Koncz-Kalman Z, Koncz C, Dudler R, Blakeslee JJ, Murphy AS, Martinoia E, Schulz B. TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19. Mol Biol Cell. 2003 Oct;14(10):4238-49. Epub 2003 Aug 7. PMID:14517332 doi:http://dx.doi.org/10.1091/mbc.E02-10-0698
  5. ↑ Lin R, Wang H. Two homologous ATP-binding cassette transporter proteins, AtMDR1 and AtPGP1, regulate Arabidopsis photomorphogenesis and root development by mediating polar auxin transport. Plant Physiol. 2005 Jun;138(2):949-64. PMID:15908594 doi:10.1104/pp.105.061572
  6. ↑ Geisler M, Blakeslee JJ, Bouchard R, Lee OR, Vincenzetti V, Bandyopadhyay A, Titapiwatanakun B, Peer WA, Bailly A, Richards EL, Ejendal KF, Smith AP, Baroux C, Grossniklaus U, Müller A, Hrycyna CA, Dudler R, Murphy AS, Martinoia E. Cellular efflux of auxin catalyzed by the Arabidopsis MDR/PGP transporter AtPGP1. Plant J. 2005 Oct;44(2):179-94. PMID:16212599 doi:10.1111/j.1365-313X.2005.02519.x
  7. ↑ Sidler M, Hassa P, Hasan S, Ringli C, Dudler R. Involvement of an ABC transporter in a developmental pathway regulating hypocotyl cell elongation in the light. Plant Cell. 1998 Oct;10(10):1623-36. PMID:9761790 doi:10.1105/tpc.10.10.1623

9jup, resolution 3.10Å

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