Styrene oxide isomerase: Difference between revisions
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'''Styrene oxide isomerase''' (SOI) is an enzyme (EC 5.3.99.7) that catalyses isomerization of styrene oxide to phenylacetaldehyde. SOI is one of the rate-limiting step enzyme in bacterial styrene degradation pathways. | '''Styrene oxide isomerase''' (SOI) is an enzyme (EC 5.3.99.7) that catalyses isomerization of styrene oxide to phenylacetaldehyde. SOI is one of the rate-limiting step enzyme in bacterial styrene degradation pathways. | ||
<StructureSection load='8PNV' size='340' side='right' caption='The cryo-EM structure of the SOI-NB complex reveals that the quaternary structure of SOI consists of a homo-trimeric assembly. Each nanobody binds at the interface of two SOI protomers. Additionally, two nanobody molecules interact with each other, resulting in the formation of a dimer of trimer assemblies within the SOI-nanobody complex | <StructureSection load='8PNV' size='340' side='right' caption='The cryo-EM structure of the SOI-NB complex reveals that the quaternary structure of SOI consists of a homo-trimeric assembly. Each nanobody binds at the interface of two SOI protomers. Additionally, two nanobody molecules interact with each other, resulting in the formation of a dimer of trimer assemblies within the SOI-nanobody complex (PDB code [[8pnv]])' scene=''> | ||
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== Structural features == | == Structural features == | ||
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== Applications == | == Applications == | ||
SOI catalyzes the Meinwald rearrangement, a Lewis-acid-catalyzed isomerization of aryl epoxides into aryl acetaldehydes. Aryl epoxides are valuable chemical precursors used in numerous industrial applications. Traditionally, converting aryl epoxides to carbonyl compounds requires harsh, corrosive chemicals and high temperatures, which result in product mixtures and environmental pollution. In contrast, SOI is highly stereospecific, making it a promising alternative for catalyzing this important reaction in industrial applications. | SOI catalyzes the Meinwald rearrangement, a Lewis-acid-catalyzed isomerization of aryl epoxides into aryl acetaldehydes. Aryl epoxides are valuable chemical precursors used in numerous industrial applications. Traditionally, converting aryl epoxides to carbonyl compounds requires harsh, corrosive chemicals and high temperatures, which result in product mixtures and environmental pollution. In contrast, SOI is highly stereospecific, making it a promising alternative for catalyzing this important reaction in industrial applications. | ||
==3D structures of SOI== | |||
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[[8pnv]] - PsSOI + nanobody - Pseudomonas - Cryo EM | |||
[[8pnu]] - PsSOI + nanobody + inhibitor - Cryo EM | |||
</StructureSection> | </StructureSection> | ||
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3. Khanppnavar, B., Choo, J.P.S., Hagedoorn, PL. et al. Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase. Nature Chemistry. (2024) https://doi.org/10.1038/s41557-024-01523-y | 3. Khanppnavar, B., Choo, J.P.S., Hagedoorn, PL. et al. Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase. Nature Chemistry. (2024) https://doi.org/10.1038/s41557-024-01523-y | ||
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