Epidermal growth factor receptor substrate: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-<StructureSection load='7tzk' size='340' side='right' caption='Caption for this structure' scene=''>
+<StructureSection load='7tzk' size='340' side='right' caption='Human Eps8 SH3 domino (cyan, green) complex with TS33 secreted effector NleH homolog peptide (pink, yellow) (PDB code [[7tzk]])' scene='10/1046375/Cv/1'>
 == Function ==
-'''Epidermal growth factor receptor substrate 8''' (Eps8) is a substrate for receptor tyrosine kinases<ref>PMID:8404850</ref>.  Eps8 i overexpressed in human pituitary tumors<ref>PMID:19116338</ref>.  Eps8 has a role in amplifying growth factor signaling in human pituitary tumors to promote proliferation and cell survival.  Eps8 enable actin binding activity and small GTPase binding activity.  '''Epidermal growth factor receptor substrate 15''' (Eps15) is a component of the endocytic machinery.  Eps15 structur is comprised of N-terminal which contains 3 SH3 domains, a central coiled-coil region and a C-terminal region containing multiple copies of Asp-Pro-Phe<ref>PMID:10481267</ref>.
+'''Epidermal growth factor receptor substrate 8''' (Eps8) is a substrate for receptor tyrosine kinases<ref>PMID:8404850</ref>. Eps8 i overexpressed in human pituitary tumors<ref>PMID:19116338</ref>. Eps8 has a role in amplifying growth factor signaling in human pituitary tumors to promote proliferation and cell survival.  Eps8 enable actin binding activity and small GTPase binding activity.  The actin bundling activity of Eps8 is hindered by its phosphorylation by kinase.  <br />
+'''Epidermal growth factor receptor substrate 15''' (Eps15) is a component of the endocytic machinery. Eps15 structur is comprised of N-terminal which contains 3 SH3 domains, a central coiled-coil region and a C-terminal region containing multiple copies of Asp-Pro-Phe<ref>PMID:10481267</ref>.<br />
+See also [[Epidermal growth factor]] and [[Epidermal Growth Factor Receptor]].
 == Disease ==
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 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+The 3D structure of the complex between Eps8 SH3 domain and the kinase NleH peptide shows <scene name='10/1046375/Cv/3'>the interaction of the PxxDY motif with Eps8 via multiple hydrogen bonds</scene><ref>PMID:35976880</ref> ([[7tzk]]). The water molecules are shown as red spheres. The C-terminal SAM domain of Eps8 contains the <scene name='10/1046375/Cv/4'>actin binding motif LNK</scene> ([[2e8m]]) and the phosphorylated Ser residue.
 == Epidermal growth factor receptor substrate 3D structures==