9bhp: Difference between revisions
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New page: '''Unreleased structure''' The entry 9bhp is ON HOLD Authors: Pourfarjam, Y., Goldgur, Y., Cuevas-Navarro, A., Lito, P. Description: Crystal structure of KRAS G12C in a transition stat... |
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==Crystal structure of KRAS G12C in a transition state mimetic complex with CYPA and RMC-7977== | |||
<StructureSection load='9bhp' size='340' side='right'caption='[[9bhp]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9bhp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BHP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BHP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AF3:ALUMINUM+FLUORIDE'>AF3</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZNI:(1R,5S,6r)-N-[(1P,7S,9S,13S,20M)-20-{5-(4-cyclopropylpiperazin-1-yl)-2-[(1S)-1-methoxyethyl]pyridin-3-yl}-21-ethyl-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-3-oxabicyclo[3.1.0]hexane-6-carboxamide+(non-preferred+name)'>ZNI</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bhp OCA], [https://pdbe.org/9bhp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bhp RCSB], [https://www.ebi.ac.uk/pdbsum/9bhp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bhp ProSAT]</span></td></tr> | ||
[[Category: Cuevas-Navarro | </table> | ||
[[Category: Goldgur | == Function == | ||
[[Category: Pourfarjam | [https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cuevas-Navarro A]] | |||
[[Category: Goldgur Y]] | |||
[[Category: Lito P]] | |||
[[Category: Pourfarjam Y]] | |||
Latest revision as of 11:14, 6 November 2024
Crystal structure of KRAS G12C in a transition state mimetic complex with CYPA and RMC-7977Crystal structure of KRAS G12C in a transition state mimetic complex with CYPA and RMC-7977
Structural highlights
FunctionPPIA_HUMAN PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
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