Cullin-associated NEDD8-disassociated protein: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

@@ Line 1: / Line 1: @@
-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
+<StructureSection load='7z8r' size='340' side='right' caption='Human CAND1 (yellow) complex with cullin1 (pink) and RBX1 (blue) (PDB id [[7z8r]])' scene=''>
 == Function ==
-'''Cullin-associated NEDD8-disassociated protein 1''' (CAND1) is a protein exchange factor that accelerates the rate at which cullin1-Rbx1 equilibrates with multiple F-box proteins and thus controls the SCF ubiquitin ligase repertoire<ref>PMID:23453757</ref>. CAND1 plays a vital role in cullin-RING E3 ligase ubiquitin proteasome systems which control protein degradation.  In plants, silencing CAND1 expression results in dwarfing, early flowering, low seed germination percentage and delayed germination<ref>PMID:31916084</ref>.
+'''Cullin-associated NEDD8-disassociated protein 1''' (CAND1) is a protein exchange factor that accelerates the rate at which cullin1-Rbx1 equilibrates with multiple F-box proteins and thus controls the SCF ubiquitin ligase repertoire<ref>PMID:23453757</ref>. CAND1 plays a vital role in cullin-RING E3 ligase ubiquitin proteasome systems which control protein degradation.  '''Cullin-associated NEDD8-disassociated protein 2''' (CAND2) is linked to mTOR singnaling<ref>PMID:34605609</ref>.
 == Disease ==
 == Relevance ==
+In plants, silencing CAND1 expression results in dwarfing, early flowering, low seed germination percentage and delayed germination<ref>PMID:31916084</ref>.  CAND1 protects against cardiac hypertrophy and heart failure by inducing the degradation of calcineurin<ref>PMID:35661710</ref>.
+CAND1 mitigates nonalcoholic fatty liver disease<ref>PMID:37528093</ref>.
 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+The 3D structure of the complex between CAND1, cullin1 and RBX as well as other 3D structures of the SCF ubiquitin E3 ligases provide a mechanism of multiprotein complex assembly that averts supply chain problems and rapidly establishes protein degradation pathways needed for cellular regulation<ref>PMID:37028429</ref>.
+== 3D structures of cullin-associated NEDD8-disassociated protein ==
+[[CAND1 3D structures]]
 </StructureSection>
 == References ==
 <references/>
+[[Category:Topic Page]]