Sodium/glucose cotransporter: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Alexander Berchansky

@@ Line 1: / Line 1: @@
-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
+<StructureSection load='8hez' size='340' side='right' caption='Human glycosylated SGLT2 (cyan) complex with PDZK1-interacting protein (green), drug dapagliflozin and Na+ ion (PDB code [[8hez]])' scene='10/1042600/Cv/1'>
-This is a default text for your page '''Sodium/glucose cotransporter'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
 == Function ==
-'''Sodium/glucose cotransporter''' (SGLT) is responsible for glucose absorption across membranes.  SGLT1 and SGLT2 which are expressed in different tissues, have similar active sites but differ in their non-active site structures.  SGLT1 is responsible of glucose absorption in the small intestine and SGLT2 in kidney<ref>PMID:26125647</ref>.
+'''Sodium/glucose cotransporter''' (SGLT) is responsible for glucose absorption across membranes.  SGLT1 and SGLT2 which are expressed in different tissues, have similar active sites but differ in their non-active site structures.  '''SGLT1''' is responsible of glucose absorption in the small intestine and '''SGLT2''' in kidney<ref>PMID:26125647</ref>.
 == Disease ==
@@ Line 13: / Line 10: @@
 == Relevance ==
-SGLT2 inhibitors aid in hypertension, acute cardiac failure, bradycardia, acute pulmonary oedema, asthma, bronchitis and COPD<ref>PMID:36819350</ref>..
+SGLT2 inhibitors aid in hypertension, acute cardiac failure, bradycardia, acute pulmonary oedema, asthma, bronchitis and COPD<ref>PMID:36819350</ref>.
 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+The drug Dapagliflozin contains a <scene name='10/1042600/Cv/5'>glucose moiety which stacks against residue Y290</scene> of SGLT2. The <scene name='10/1042600/Cv/6'>glucose moiety forms multiple H-bonds</scene> to SGLT2<ref>PMID:38057552</ref>. Water molecule is shown as red sphere.
+See also:
+*[[Canagliflozin]]
+*[[Dapagliflozin]]
+*[[Empagliflozin]]
 ==3D structures of sodium/glucose cotransporter==
+[[Sodium/glucose cotransporter 3D structures]]
 </StructureSection>