8xxr: Difference between revisions
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==Structure of CXCR2 bound to CXCL6 (CXCR2-CXCL6-Go Full map)== | |||
<StructureSection load='8xxr' size='340' side='right'caption='[[8xxr]], [[Resolution|resolution]] 3.17Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8xxr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XXR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.17Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xxr OCA], [https://pdbe.org/8xxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xxr RCSB], [https://www.ebi.ac.uk/pdbsum/8xxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xxr ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Autosomal recessive severe congenital neutropenia due to CXCR2 deficiency. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CXCR2_HUMAN CXCR2_HUMAN] Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Banerjee R]] | |||
[[Category: Ganguly M]] | |||
[[Category: Nureki O]] | |||
[[Category: Saha S]] | |||
[[Category: Sano FK]] | |||
[[Category: Sharma S]] | |||
[[Category: Shihoya W]] | |||
[[Category: Shukla AK]] | |||