8xx3: Difference between revisions

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'''Unreleased structure'''


The entry 8xx3 is ON HOLD  until Paper Publication
==Structure of CXCR2 bound to CXCL3 (CXCR2-CXCL3-Go Full map)==
 
<StructureSection load='8xx3' size='340' side='right'caption='[[8xx3]], [[Resolution|resolution]] 3.38&Aring;' scene=''>
Authors: Sano, F.K., Saha, S., Sharma, S., Ganguly, M., Shihoya, W., Nureki, O., Shukla, A.K., Banerjee, R.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8xx3]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XX3 FirstGlance]. <br>
Description: Structure of CXCR2 bound to CXCL3 (CXCR2-CXCL3-Go Full map)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.38&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xx3 OCA], [https://pdbe.org/8xx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xx3 RCSB], [https://www.ebi.ac.uk/pdbsum/8xx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xx3 ProSAT]</span></td></tr>
[[Category: Nureki, O]]
</table>
[[Category: Shukla, A.K]]
== Function ==
[[Category: Saha, S]]
[https://www.uniprot.org/uniprot/CXCL3_HUMAN CXCL3_HUMAN] Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.<ref>PMID:10095777</ref>
[[Category: Sharma, S]]
== References ==
[[Category: Banerjee, R]]
<references/>
[[Category: Ganguly, M]]
__TOC__
[[Category: Sano, F.K]]
</StructureSection>
[[Category: Shihoya, W]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Banerjee R]]
[[Category: Ganguly M]]
[[Category: Nureki O]]
[[Category: Saha S]]
[[Category: Sano FK]]
[[Category: Sharma S]]
[[Category: Shihoya W]]
[[Category: Shukla AK]]

Latest revision as of 09:14, 15 January 2025

Structure of CXCR2 bound to CXCL3 (CXCR2-CXCL3-Go Full map)Structure of CXCR2 bound to CXCL3 (CXCR2-CXCL3-Go Full map)

Structural highlights

8xx3 is a 7 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.38Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CXCL3_HUMAN Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.[1]

References

  1. ↑ Wuyts A, Govaerts C, Struyf S, Lenaerts JP, Put W, Conings R, Proost P, Van Damme J. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. Eur J Biochem. 1999 Mar;260(2):421-9. PMID:10095777

8xx3, resolution 3.38Å

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OCA
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