8vof: Difference between revisions

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'''Unreleased structure'''


The entry 8vof is ON HOLD  until Paper Publication
==GI targeted CpPI4K inhibitor==
 
<StructureSection load='8vof' size='340' side='right'caption='[[8vof]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
Authors: Knapp, M.S., Cuellar, C., Mamo, M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8vof]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VOF FirstGlance]. <br>
Description: GI targeted CpPI4K inhibitor
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vof OCA], [https://pdbe.org/8vof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vof RCSB], [https://www.ebi.ac.uk/pdbsum/8vof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vof ProSAT]</span></td></tr>
[[Category: Knapp, M.S]]
</table>
[[Category: Cuellar, C]]
== Function ==
[[Category: Mamo, M]]
[https://www.uniprot.org/uniprot/PI4KB_HUMAN PI4KB_HUMAN] Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).<ref>PMID:9405935</ref> <ref>PMID:10559940</ref> <ref>PMID:12749687</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Cuellar C]]
[[Category: Knapp MS]]
[[Category: Mamo M]]

Latest revision as of 08:38, 4 September 2024

GI targeted CpPI4K inhibitorGI targeted CpPI4K inhibitor

Structural highlights

8vof is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PI4KB_HUMAN Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity).[1] [2] [3]

References

  1. ↑ Suzuki K, Hirano H, Okutomi K, Suzuki M, Kuga Y, Fujiwara T, Kanemoto N, Isono K, Horie M. Identification and characterization of a novel human phosphatidylinositol 4-kinase. DNA Res. 1997 Aug 31;4(4):273-80. PMID:9405935
  2. ↑ Godi A, Pertile P, Meyers R, Marra P, Di Tullio G, Iurisci C, Luini A, Corda D, De Matteis MA. ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex. Nat Cell Biol. 1999 Sep;1(5):280-7. PMID:10559940 doi:http://dx.doi.org/10.1038/12993
  3. ↑ Heilmeyer LM Jr, Vereb G Jr, Vereb G, Kakuk A, Szivak I. Mammalian phosphatidylinositol 4-kinases. IUBMB Life. 2003 Feb;55(2):59-65. PMID:12749687 doi:http://dx.doi.org/10.1002/tbmb.718540873

8vof, resolution 3.00Å

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