8v3o: Difference between revisions
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The entry | ==CCP5 in complex with Glu-P-peptide 1 transition state analog== | ||
<StructureSection load='8v3o' size='340' side='right'caption='[[8v3o]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8v3o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V3O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V3O FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BIX:(2S)-2-{[(S)-[(3S)-3-AMINO-3-CARBOXYPROPYL](HYDROXY)PHOSPHORYL]METHYL}PENTANEDIOIC+ACID'>BIX</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v3o OCA], [https://pdbe.org/8v3o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v3o RCSB], [https://www.ebi.ac.uk/pdbsum/8v3o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v3o ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/CBPC5_HUMAN CBPC5_HUMAN] Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CBPC5_HUMAN CBPC5_HUMAN] Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.[UniProtKB:Q09M02] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen J]] | |||
[[Category: Gruschus JM]] | |||
[[Category: Liu Y]] | |||
[[Category: Roll-Mecak A]] | |||
[[Category: Szyk A]] | |||
[[Category: Tanner ME]] | |||
[[Category: Tjandra N]] | |||
[[Category: Zehr EA]] | |||
Latest revision as of 15:23, 17 July 2024
CCP5 in complex with Glu-P-peptide 1 transition state analogCCP5 in complex with Glu-P-peptide 1 transition state analog
Structural highlights
DiseaseCBPC5_HUMAN Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. FunctionCBPC5_HUMAN Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side-chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.[UniProtKB:Q09M02] |
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