8up4: Difference between revisions

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'''Unreleased structure'''


The entry 8up4 is ON HOLD  until Paper Publication
==Crystal structure of Lsd18 (a flavin-dependent monooxygenase)==
 
<StructureSection load='8up4' size='340' side='right'caption='[[8up4]], [[Resolution|resolution]] 1.51&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8up4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_lasalocidi Streptomyces lasalocidi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UP4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UP4 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.51&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ELY:N~6~,N~6~-DIETHYL-L-LYSINE'>ELY</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8up4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8up4 OCA], [https://pdbe.org/8up4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8up4 RCSB], [https://www.ebi.ac.uk/pdbsum/8up4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8up4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LSD18_STRLS LSD18_STRLS] May catalyze the stereoselective double epoxidation reaction leading to bisepoxyprelasalocid A, a bisepoxide intermediate in the biosynthesis of the polyether antibiotic lasalocid A.<ref>PMID:19025863</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces lasalocidi]]
[[Category: Chen X]]
[[Category: Kim CY]]
[[Category: Wang Q]]

Latest revision as of 09:25, 18 December 2024

Crystal structure of Lsd18 (a flavin-dependent monooxygenase)Crystal structure of Lsd18 (a flavin-dependent monooxygenase)

Structural highlights

8up4 is a 2 chain structure with sequence from Streptomyces lasalocidi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.51Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LSD18_STRLS May catalyze the stereoselective double epoxidation reaction leading to bisepoxyprelasalocid A, a bisepoxide intermediate in the biosynthesis of the polyether antibiotic lasalocid A.[1]

References

  1. ↑ Smith L, Hong H, Spencer JB, Leadlay PF. Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure. Chembiochem. 2008 Dec 15;9(18):2967-75. doi: 10.1002/cbic.200800585. PMID:19025863 doi:http://dx.doi.org/10.1002/cbic.200800585

8up4, resolution 1.51Å

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OCA
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