8wp8: Difference between revisions

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-'''Unreleased structure'''
-The entry 8wp8 is ON HOLD
+==Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2==
+<StructureSection load='8wp8' size='340' side='right'caption='[[8wp8]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
-Authors: Li, L.J., Gu, Y.H., Qi, J.X., Gao, G.F.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8wp8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WP8 FirstGlance]. <br>
-Description: Cryo-EM structure of SARS-CoV-2 Omicron BA.2.86 RBD in complex with human ACE2
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Qi, J.X]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wp8 OCA], [https://pdbe.org/8wp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wp8 RCSB], [https://www.ebi.ac.uk/pdbsum/8wp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wp8 ProSAT]</span></td></tr>
-[[Category: Gao, G.F]]
+</table>
-[[Category: Li, L.J]]
+== Function ==
-[[Category: Gu, Y.H]]
+[https://www.uniprot.org/uniprot/ACE2_HUMAN ACE2_HUMAN] Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.<ref>PMID:10969042</ref> <ref>PMID:10924499</ref> <ref>PMID:14647384</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Severe acute respiratory syndrome coronavirus 2]]
+[[Category: Gao GF]]
+[[Category: Gu YH]]
+[[Category: Li LJ]]
+[[Category: Qi JX]]