8qbd: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8qbd is ON HOLD
+==Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol, PI(4,5)P2 35:20:20:15:10)==
+<StructureSection load='8qbd' size='340' side='right'caption='[[8qbd]], [[Resolution|resolution]] 3.61&Aring;' scene=''>
-Authors: Kefauver, J.M., Zou, L., Desfosses, A., Loewith, R.J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8qbd]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QBD FirstGlance]. <br>
-Description: Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol, PI(4,5)P2 35:20:20:15:10)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.61&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>
-[[Category: Loewith, R.J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qbd OCA], [https://pdbe.org/8qbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qbd RCSB], [https://www.ebi.ac.uk/pdbsum/8qbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qbd ProSAT]</span></td></tr>
-[[Category: Zou, L]]
+</table>
-[[Category: Desfosses, A]]
+== Function ==
-[[Category: Kefauver, J.M]]
+[https://www.uniprot.org/uniprot/PIL1_YEAST PIL1_YEAST] Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase PKH1/PHK2 activity and regulating their downstream CWI pathways PKC1-MAP kinase pathway and protein kinase YPK1 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress.<ref>PMID:15016821</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Saccharomyces cerevisiae]]
+[[Category: Desfosses A]]
+[[Category: Kefauver JM]]
+[[Category: Loewith RJ]]
+[[Category: Zou L]]