8j6d: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 8j6d is ON HOLD
+==Structure of EP141-C3aR-Go complex==
+<StructureSection load='8j6d' size='340' side='right'caption='[[8j6d]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8j6d]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J6D FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j6d OCA], [https://pdbe.org/8j6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j6d RCSB], [https://www.ebi.ac.uk/pdbsum/8j6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j6d ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/C3AR_HUMAN C3AR_HUMAN] Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The complement system is a critical part of our innate immune response, and the terminal products of this cascade, anaphylatoxins C3a and C5a, exert their physiological and pathophysiological responses primarily via two GPCRs, C3aR and C5aR1. However, the molecular mechanism of ligand recognition, activation, and signaling bias of these receptors remains mostly elusive. Here, we present nine cryo-EM structures of C3aR and C5aR1 activated by their natural and synthetic agonists, which reveal distinct binding pocket topologies of complement anaphylatoxins and provide key insights into receptor activation and transducer coupling. We also uncover the structural basis of a naturally occurring mechanism to dampen the inflammatory response of C5a via proteolytic cleavage of the terminal arginine and the G-protein signaling bias elicited by a peptide agonist of C3aR identified here. In summary, our study elucidates the innerworkings of the complement anaphylatoxin receptors and should facilitate structure-guided drug discovery to target these receptors in a spectrum of disorders.
-Authors: Yadav, M.K., Yadav, R., Maharana, J., Sarma, P., Banerjee, R., Shukla, A.K., Gati, C.
+Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.,Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C Cell. 2023 Oct 26;186(22):4956-4973.e21. doi: 10.1016/j.cell.2023.09.020. Epub , 2023 Oct 17. PMID:37852260<ref>PMID:37852260</ref>
-Description: Structure of EP141-C3aR-Go complex
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Shukla, A.K]]
+<div class="pdbe-citations 8j6d" style="background-color:#fffaf0;"></div>
-[[Category: Yadav, M.K]]
-[[Category: Sarma, P]]
+==See Also==
-[[Category: Maharana, J]]
+*[[Transducin 3D structures|Transducin 3D structures]]
-[[Category: Banerjee, R]]
+== References ==
-[[Category: Gati, C]]
+<references/>
-[[Category: Yadav, R]]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Banerjee R]]
+[[Category: Gati C]]
+[[Category: Maharana J]]
+[[Category: Sarma P]]
+[[Category: Shukla AK]]
+[[Category: Yadav MK]]
+[[Category: Yadav R]]