8ce6: Difference between revisions

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-'''Unreleased structure'''
-The entry 8ce6 is ON HOLD
+==Crystal structure of human Cd11b I domain in P212121 space group==
+<StructureSection load='8ce6' size='340' side='right'caption='[[8ce6]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
-Authors: Koekemoer, L., Williams, E., Ni, X., Gao, Q., Coker, J., MacLean, E.M., Wright, N.D., Marsden, B., Von Delft, F., Schwenzer, A., Midwood, K.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8ce6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CE6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CE6 FirstGlance]. <br>
-Description: Crystal structure of human Cd11b in P212121 spacegroup
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.582&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Midwood, K]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ce6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ce6 OCA], [https://pdbe.org/8ce6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ce6 RCSB], [https://www.ebi.ac.uk/pdbsum/8ce6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ce6 ProSAT]</span></td></tr>
-[[Category: Wright, N.D]]
+</table>
-[[Category: Williams, E]]
+== Disease ==
-[[Category: Von Delft, F]]
+[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:[https://omim.org/entry/609939 609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
-[[Category: Koekemoer, L]]
+== Function ==
-[[Category: Schwenzer, A]]
+[https://www.uniprot.org/uniprot/ITAM_HUMAN ITAM_HUMAN] Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
-[[Category: Ni, X]]
+__TOC__
-[[Category: Marsden, B]]
+</StructureSection>
-[[Category: Gao, Q]]
+[[Category: Homo sapiens]]
-[[Category: Maclean, E.M]]
+[[Category: Large Structures]]
-[[Category: Coker, J]]
+[[Category: Coker J]]
+[[Category: Gao Q]]
+[[Category: Koekemoer L]]
+[[Category: MacLean EM]]
+[[Category: Marsden B]]
+[[Category: Midwood K]]
+[[Category: Ni X]]
+[[Category: Schwenzer A]]
+[[Category: Von Delft F]]
+[[Category: Williams E]]
+[[Category: Wright ND]]