8hjc: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 8hjc is ON HOLD
+==Solution structure of cysteine-rich peptide Bidentatide (Achyranthes bidentata peptide)==
+<StructureSection load='8hjc' size='340' side='right'caption='[[8hjc]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8hjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Achyranthes_bidentata Achyranthes bidentata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HJC FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hjc OCA], [https://pdbe.org/8hjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hjc RCSB], [https://www.ebi.ac.uk/pdbsum/8hjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hjc ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Cysteine-rich peptides (CRPs) are stable molecules that contain multiple disulphide bonds. Various CRPs are found in plants and animals, representing potential compounds for drug development with diverse activities. Modification of CRPs, such as glycation, has attracted increased attention due to its special structural and functional properties. Hence, this study explored a CRP isolated from the Chinese herb Achyranthes bidentata Blume, which contains a glycation modification. Herein, a reverse phase high-performance liquid chromatography system with mobile phases was used to extract and purify the peptide. The eluted peptide was detected using high resolution mass spectrometry and structurally identified using high resolution mass spectrometry and nuclear magnetic resonance. The effect of the peptide on the viability of N-methyl-D-aspartic acid (NMDA)-induced HT22 cells was determined using a cell assay. Here, a new cysteine-rich glycation peptide, termed glycation-bidentatide (Gly-BTP), with three pairs of disulphide bonds and a glycation modification at the N-terminus linked to cysteine, was discovered. Cell bioactivity assay results suggested that Gly-BTP might be a potential therapeutic and provide a neuroprotective effect in NMDA-induced HT22 murine hippocampal neuronal cells. The discovery of Gly-BTP will promote the understanding of the role of CRPs in neuroprotection.
-Authors: Feng, Y., He, M., Zhang, X.
+Discovery of a cysteine-rich peptide with glycation modification from Achyranthes bidentata Blume.,He M, Feng Y, Wang Y, Cheng M, Zhang X, Zhang L Fitoterapia. 2022 Nov;163:105338. doi: 10.1016/j.fitote.2022.105338. Epub 2022 , Oct 19. PMID:36270560<ref>PMID:36270560</ref>
-Description: Solution structure of cysteine-rich peptide Bidentatide (Achyranthes bidentata peptide)
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: He, M]]
+<div class="pdbe-citations 8hjc" style="background-color:#fffaf0;"></div>
-[[Category: Zhang, X]]
+== References ==
-[[Category: Feng, Y]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Achyranthes bidentata]]
+[[Category: Large Structures]]
+[[Category: Feng Y]]
+[[Category: He M]]
+[[Category: Zhang X]]