8f2r: Difference between revisions
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New page: '''Unreleased structure''' The entry 8f2r is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Human CCC complex== | |||
<StructureSection load='8f2r' size='340' side='right'caption='[[8f2r]], [[Resolution|resolution]] 3.12Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8f2r]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F2R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.12Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f2r OCA], [https://pdbe.org/8f2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f2r RCSB], [https://www.ebi.ac.uk/pdbsum/8f2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f2r ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/COMD1_HUMAN COMD1_HUMAN] Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.<ref>PMID:14685266</ref> <ref>PMID:15799966</ref> <ref>PMID:16573520</ref> <ref>PMID:17309234</ref> <ref>PMID:17183367</ref> <ref>PMID:20048074</ref> <ref>PMID:20595380</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Berger I]] | |||
[[Category: Berger-Schaffitzel C]] | |||
[[Category: Borucu U]] | |||
[[Category: Butkovic R]] | |||
[[Category: Caruana NJ]] | |||
[[Category: Chen K]] | |||
[[Category: Chilton M]] | |||
[[Category: Collins BM]] | |||
[[Category: Croll TI]] | |||
[[Category: Cullen PJ]] | |||
[[Category: Derivery E]] | |||
[[Category: Ghai R]] | |||
[[Category: Hall RJ]] | |||
[[Category: Healy MD]] | |||
[[Category: Heesom KJ]] | |||
[[Category: Kadapalakere SY]] | |||
[[Category: Kato K]] | |||
[[Category: McConville C]] | |||
[[Category: McNally KE]] | |||
[[Category: Moody ERR]] | |||
[[Category: Nguyen THD]] | |||
[[Category: Palmer CS]] | |||
[[Category: Planelles-Herrero VJ]] | |||
[[Category: Ross J]] | |||
[[Category: Sacharz J]] | |||
[[Category: Saitoh S]] | |||
[[Category: Shaw S]] | |||
[[Category: Stroud DA]] | |||
[[Category: Williams TA]] | |||