8ew5: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[8ew5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombus_ignitus Bombus ignitus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EW5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[8ew5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombus_ignitus Bombus ignitus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EW5 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ew5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ew5 OCA], [https://pdbe.org/8ew5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ew5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ew5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ew5 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ew5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ew5 OCA], [https://pdbe.org/8ew5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ew5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ew5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ew5 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Function ==
== Publication Abstract from PubMed ==
[https://www.uniprot.org/uniprot/A0A6J3L7M6_9HYME A0A6J3L7M6_9HYME]
Four insect orders have flight muscles that are both asynchronous and indirect; they are asynchronous in that the wingbeat frequency is decoupled from the frequency of nervous stimulation and indirect in that the muscles attach to the thoracic exoskeleton instead of directly to the wing. Flight muscle thick filaments from two orders, Hemiptera and Diptera, have been imaged at a subnanometer resolution, both of which revealed a myosin tail arrangement referred to as "curved molecular crystalline layers". Here, we report a thick filament structure from the indirect flight muscles of a third insect order, Hymenoptera, the Asian bumble bee Bombus&amp;nbsp;ignitus. The myosin tails are in general agreement with previous determinations from Lethocerus&amp;nbsp;indicus and Drosophila&amp;nbsp;melanogaster. The Skip 2 region has the same unusual structure as found in Lethocerus&amp;nbsp;indicus thick filaments, an alpha-helix discontinuity is also seen at Skip 4, but the orientation of the Skip 1 region on the surface of the backbone is less angled with respect to the filament axis than in the other two species. The heads are disordered as in Drosophila, but we observe no non-myosin proteins on the backbone surface that might prohibit the ordering of myosin heads onto the thick filament backbone. There are strong structural similarities among the three species in their non-myosin proteins within the backbone that suggest how one previously unassigned density in Lethocerus might be assigned. Overall, the structure conforms to the previously observed pattern of high similarity in the myosin tail arrangement, but differences in the non-myosin proteins.
 
Structure of the Flight Muscle Thick Filament from the Bumble Bee, Bombus ignitus, at 6 A Resolution.,Li J, Rahmani H, Abbasi Yeganeh F, Rastegarpouyani H, Taylor DW, Wood NB, Previs MJ, Iwamoto H, Taylor KA Int J Mol Sci. 2022 Dec 26;24(1):377. doi: 10.3390/ijms24010377. PMID:36613818<ref>PMID:36613818</ref>
 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 8ew5" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>

Latest revision as of 09:39, 19 June 2024

The structure of flightin within myosin thick filaments from Bombus ignitus flight muscleThe structure of flightin within myosin thick filaments from Bombus ignitus flight muscle

Structural highlights

8ew5 is a 1 chain structure with sequence from Bombus ignitus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A6J3L7M6_9HYME

8ew5, resolution 6.00Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=8ew5&oldid=4238477"